N-(叔丁氧基羰基)-L-脯氨酸-N′-甲氧基-N′-甲酰胺合成路线 （共 18 条）
反应条件
in dichloromethane 2 h; Ambient temperature; Yield given;
参考文献
Coz, Sylvie Le; Mann, Andre; Thareau, Frederic; Taddei, Maurizio
Heterocycles, 1993 , vol. 36, # 9 p. 2073 - 2080
反应条件
in dichloromethane 16 h; Inert atmosphere;
参考文献
Patel, Bhavesh H.; Mason, Andrew M.; Patel, Hetal; Coombes, R. Charles; Ali, Simak; Barrett, Anthony G. M.
Journal of Organic Chemistry, 2011 , vol. 76, # 15 p. 6209 - 6217
参考文献
Drew, Michael G. B.; Gorsuch, Stephen; Mann, John; Yoshida, Shimon
Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 10 p. 1627 - 1636
反应条件
lithium aluminium tetrahydride T=0°C; 0.25 h;
参考文献
Falkiewicz; Wisniowski; Kolodziejczyk; Wisniewski
Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 4-7 p. 1393 - 1397
反应条件
1: Boc-Pro-N(OMe)Me With diisobutylaluminium hydride in n-heptane; dichloromethane T=-78°C; 2: (1-Diazo-2-oxo-propyl)-phosphonic acid dimethyl ester With potassium carbonate in methanol; n-heptane; dichloromethane T=20°C; Further stages.;
参考文献
Ying, Weijiang; Herndon, James W.
European Journal of Organic Chemistry, 2013 , # 15 p. 3112 - 3122
反应条件
1: 89 percent / AlLiH4 / tetrahydrofuran / 1 h / Ambient temperature 2: 72 percent / tetrahydrofuran / 3 h / Ambient temperature 3: 90 percent / NaH / dimethylformamide / 24 h / Ambient temperature 4: NaIO4, 60 percent aq. RuO2 / acetonitrile; CCl4 / 6 h 5: 1 M KMnO4 / 2-methyl-propan-2-ol / 0.25 h View Scheme
参考文献
Roux, Florence; Maugras, Isabelle; Poncet, Joel; Niel, Gilles; Jouin, Patrick
Tetrahedron, 1994 , vol. 50, # 18 p. 5345 - 5360
反应条件
1: Boc-Pro-N(OMe)Me With diisobutylaluminium hydride in n-heptane; dichloromethane T=-78°C; 2: (1-Diazo-2-oxo-propyl)-phosphonic acid dimethyl ester With potassium carbonate in methanol; n-heptane; dichloromethane T=20°C; Further stages.;
参考文献
Ying, Weijiang; Herndon, James W.
European Journal of Organic Chemistry, 2013 , # 15 p. 3112 - 3122
反应条件
1: 89 percent / AlLiH4 / tetrahydrofuran / 1 h / Ambient temperature 2: 72 percent / tetrahydrofuran / 3 h / Ambient temperature View Scheme
参考文献
Roux, Florence; Maugras, Isabelle; Poncet, Joel; Niel, Gilles; Jouin, Patrick
Tetrahedron, 1994 , vol. 50, # 18 p. 5345 - 5360
