4,5,6,7-四氢噻吩并[3,2-c]吡啶-2-醇 2-乙酸酯盐酸盐合成路线 (共 3 条)
反应条件
triethylamine in dichloromethane T=-15 - 20°C; Product distribution / selectivity;
参考文献
WO2011/29456 A1, ;
Page/Page column 17 ;
反应条件
hydrogenchloride in diethyl ether
参考文献
SYNTHON BV; THIJS, Lambertus; ZHU, Jie; OVEREEM, Arjanne
Patent: WO2011/29456 A1, 2011 ;
Location in patent: Page/Page column 16 ;
反应条件
1: sodium hydride / N,N-dimethyl-formamide / 3 h / 20 °C / Cooling with ice-water bath
2: hydrogenchloride / diethyl ether
View Scheme
参考文献
SYNTHON BV; THIJS, Lambertus; ZHU, Jie; OVEREEM, Arjanne
Patent: WO2011/29456 A1, 2011 ;