N-CBZ-L-天冬氨酸合成路线 （共 76 条）
反应条件
1: With potassium carbonate in water T=0 - 20°C; 16 h; 2: With hydrogenchloride in water pH=1;
参考文献
DAEWOONG PHARMACEUTICAL CO., LTD.; CHOI, Soo Jin; LEE, Byung Goo; OH, Seong Soo; KIM, Yong Tae; EO, Jin Yong; KIM, Hung Sop
Patent: WO2012/148246 A2, 2012 ;
Location in patent: Page/Page column 12 ;
反应条件
lithium hydroxide; water in tetrahydrofuran 2 h;
参考文献
WO2005/107762 A2, ;
Page/Page column 268-270 ;
反应条件
triethylsilane; trifluoroacetic acid in dichloromethane 0.75 h; Ambient temperature;
参考文献
Mehta, Anita; Jaouhari, Rabih; Benson, Timothy J.; Douglas, Kenneth T.
Tetrahedron Letters, 1992 , vol. 33, # 37 p. 5441 - 5444
反应条件
in tetrahydrofuran T=23°C;
参考文献
Castano, Ana M.; Echavarren, Antonio M.
Tetrahedron, 1992 , vol. 48, # 16 p. 3377 - 3384
反应条件
triethylamine in water; acetone Ambient temperature;
参考文献
Kunieda, Takehisa; Higuchi, Tsunehiko; Abe, Yoshihiro; Hirobe, Masaaki
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 6 p. 2174 - 2181
反应条件
triethylamine in water Ambient temperature;
参考文献
Azuse; Tamura; Kinomura; Okai; Kouge; Hamatsu; Koizumi
Bulletin of the Chemical Society of Japan, 1989 , vol. 62, # 10 p. 3103 - 3108
反应条件
1: 1-bromo-butane With magnesium in tetrahydrofuran T=40°C; 2 h; 2: N-benzyloxycarbonyl-L-aspartic anhydride in tetrahydrofuran T=-78°C; 4 h; 3: With citric acid in tetrahydrofuran T=-78 - 20°C; Title compound not separated from byproducts;
参考文献
Tetrahedron Asymmetry, , vol. 17, # 14 p. 2120 - 2125
反应条件
1: 3-methoxybromobenzene With magnesium in tetrahydrofuran T=40°C; 2 h; 2: N-benzyloxycarbonyl-L-aspartic anhydride in tetrahydrofuran T=-78°C; 4 h; 3: With citric acid in tetrahydrofuran T=-78 - 20°C; Title compound not separated from byproducts;
参考文献
Tetrahedron Asymmetry, , vol. 17, # 14 p. 2120 - 2125
反应条件
1: in tetrahydrofuran T=-78°C; 4 h; 2: With citric acid in tetrahydrofuran Title compound not separated from byproducts;
参考文献
Tetrahedron Asymmetry, , vol. 17, # 14 p. 2120 - 2125
反应条件
1: With Wang resin 2: With sodium trimethyl-silanolate in dichloromethane 24 h; 3: With scavenger TIPS; trifluoroacetic acid in dichloromethane
参考文献
Tetrahedron Letters, , vol. 46, # 11 p. 1795 - 1797
