N-CBZ-L-天冬氨酸合成路线 （共 76 条）
反应条件
potassium carbonate in water 4 h; Heating;
参考文献
Hernandez, J. Nicolas; Martin, Victor S.
Journal of Organic Chemistry, 2004 , vol. 69, # 10 p. 3590 - 3592
反应条件
1.1: 89 percent / KHCO3 / dimethylformamide / 12 h / 22 °C 2.1: 91 percent / aq. LiOH / tetrahydrofuran / 2 h / 0 °C 3.1: 71 percent / dicyclohexylcarbodiimide; dimethylaminopyridine / CH2Cl2 / 12 h / 0 - 22 °C 4.1: 89 percent / MCPBA / CH2Cl2 / 4 h / 0 °C 5.1: 99 percent / AgClO4 / Cp2ZrCl2 / CH2Cl2 / 1 h / 22 °C 6.1: 82 percent / LiBH4; MeOH / diethyl ether / 0.25 h / Heating 7.1: 2-nitrophenyl selenocyanate; tri-n-butylphosphine / tetrahydrofuran / 0.25 h / 0 °C 7.2: 71 percent / aq. H2O2 / tetrahydrofuran / 6 h / 22 °C 8.1: 82 percent / HCl / 3 h / 0 - 22 °C View Scheme
参考文献
Wipf, Peter; Wenjing, Xu; Hongyong, Kim; Takahashi, Hidenori
Tetrahedron, 1997 , vol. 53, # 48 p. 16575 - 16596
反应条件
boron trifluoride-tetrahydrofuran complex
参考文献
Tomori, Hiroshi; Shibutani, Kuniko; Ogura, Katsuyuki
Heterocycles, 1997 , vol. 44, # 1 p. 213 - 225
反应条件
hydrogenchloride; anhydrous calcium acetate; triethylamine; thermolysin in 1,1-dimethylpropan-1-ol T=40°C; 72 h;
参考文献
Ye, Yun-Hua; Tian, Gui-Ling; Xing, Guo-Wen; Dai, Dong-Cheng; Chen, Gang; Li, Chong-Xi
Tetrahedron, 1998 , vol. 54, # 41 p. 12585 - 12596
反应条件
in N-methyl-acetamide; water
参考文献
Toyo Soda Manufacturing Co. Ltd.; (Zaidanhojin) Sagami Chemical Research Center
Patent: US4165311 A1, 1979 ;
反应条件
McIlvaine buffer; triethylamine; papain in ethyl acetate T=37°C; 72 h;
参考文献
Chen, S. T.; Wang, K. T.
Journal of Organic Chemistry, 1988 , vol. 53, # 19 p. 4589 - 4590
反应条件
thermolysin-immobilized capsule membrane in chloroform T=45°C; 24 h;
参考文献
Okahata, Yoshio; Ijiro, Kuniharu
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1988 , p. 91 - 96
反应条件
hydrogenchloride; anhydrous calcium acetate; triethylamine; thermolysin in 1,1-dimethylpropan-1-ol T=40°C; 72 h;
参考文献
Ye, Yun-Hua; Tian, Gui-Ling; Xing, Guo-Wen; Dai, Dong-Cheng; Chen, Gang; Li, Chong-Xi
Tetrahedron, 1998 , vol. 54, # 41 p. 12585 - 12596
反应条件
thermolysin in water T=40°C; pH=6.8, 4 iterations in the nucleophile pool; Yield given;
参考文献
Petkov, D. D.; Stoineva, I. B.
Tetrahedron Letters, 1984 , vol. 25, # 34 p. 3751 - 3754
反应条件
acetic anhydride in tetrahydrofuran 1 h;
参考文献
CYTOKINETICS, INC.; SMITHKLINE BEECHAM CORPORATION
Patent: WO2007/56143 A2, 2007 ;
Location in patent: Page/Page column 57 ;
