2-(4-氨基苯基)-2-甲基丙腈合成路线 (共 7 条)
反应条件
carbon palladium in ethyl acetate
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED
Patent: US2009/137595 A1, 2009 ;
反应条件
in ethyl acetate 3 h; Reflux;
参考文献
US2012/108583 A1, ;
Page/Page column 29 ;
US 20120108583 A1
反应条件
1: aqueous HNO3 2: ethanol; aqueous Na2S2O4 View Scheme
参考文献
Acta Chemica Scandinavica (1947-1973), , vol. 8, p. 1203,1207
Acta Chemica Scandinavica (1947-1973), , vol. 9, p. 210,214
反应条件
in acetic acid T=25°C; 0.5 h;
参考文献
PROGENICS PHARMACEUTICALS, INC.
Patent: WO2009/155527 A2, 2009 ;
Location in patent: Page/Page column 264 ;
WO 2009/155527 A2
参考文献
Joensson
Acta Chemica Scandinavica (1947-1973), 1954 , vol. 8, p. 1203,1207
Acta Chemica Scandinavica (1947-1973), 1955 , vol. 9, p. 210,214
反应条件
1: acetic acid / 2 h
2: hydrogen / tetrahydrofuran; methanol / 1 h / 825.08 Torr
3: triethylamine / dichloromethane / 1 h / 0 °C
4: tetrabutylammomium bromide; sodium hydroxide / water; dichloromethane / 72 h / 20 °C
View Scheme
参考文献
NOVARTIS PHARMA AG; INCYTE CORPORATION; VANNUCCHI, Alessandro M.; BOGANI, Costanza; BARTALUCCI, Niccolo
Patent: WO2013/23119 A1, 2013 ;
反应条件
1: acetic acid / 2 h
2: hydrogen / Raney-Ni / 1 h / 20 °C / 1292.9 Torr
View Scheme
参考文献
INTELLIKINE, LLC; REN, Pingda; LIU, Yi; LI, Liansheng; CHAN, Katrina; WILSON, Troy, Edward; CAMPBELL, Simon, Fraser
Patent: WO2012/116237 A2, 2012 ;
WO 2012/116237 A2