(R)-3-(甲基氨基)-1-苯基-1-丙醇合成路线 (共 6 条)
反应条件
1: (R)-N-methyl-3-phenyl-3-hydroxy-propylamine With sodium hydride in dimethyl sulfoxide 0.25 h; 2: With KOC(O)Ph in dimethyl sulfoxide T=50 - 55°C; 1 h; 3: 2-methylfluorobenzene in dimethyl sulfoxide T=50 - 120°C; 6.25 - 7.25 h;
参考文献
Chen, Bo-Fong; Li, Yan-Wei; Yeh, Jinun-Ban; Wong, Wei-Chyun
Patent: US2011/319664 A1, 2011 ;
Location in patent: Page/Page column 4 ;
反应条件
dimethylammonium 2,4-dichlorophenoxyacetate; sodium hydride Multistep reaction;
参考文献
Schneider; Goergens
Tetrahedron Asymmetry, 1992 , vol. 3, # 4 p. 525 - 528
反应条件
1: With potassium carbonate; copper(l) iodide in toluene T=148°C; Ullmann type reaction; 21 h; Heating / reflux; 2: With hydrogenchloride in water pH=1 - 2; 3: With sodium hydroxide in water pH=11 - 12;
参考文献
FERMION OY
Patent: WO2007/10082 A1, 2007 ;
Location in patent: Page/Page column 18-19 ;
反应条件
triphenylphosphine; diethylazodicarboxylate Yield given. Multistep reaction;
参考文献
Koenig, Thomas M.; Mitchell, David
Tetrahedron Letters, 1994 , vol. 35, # 9 p. 1339 - 1342
反应条件
1: With caesium carbonate; copper(l) iodide in n-butyronitrile T=130 - 140°C; 16 - 24 h; 2: With hydrogenchloride in tert-butyl methyl ether; isopropyl alcohol
参考文献
APOTEX PHARMACHEM INC.
Patent: WO2007/6132 A1, 2007 ;
Location in patent: Page/Page column 19 ;
反应条件
sodium hydride 1) DMSO, 50 deg C, 20 min, 2) DMSO, 90 deg C, 40 min; Yield given. Multistep reaction;
参考文献
Corey, E. J.; Reichard, Gregory A.
Tetrahedron Letters, 1989 , vol. 30, # 39 p. 5207 - 5210