(S)-(+)- 间硝基苯磺酸缩水甘油酯合成路线 （共 34 条）
反应条件
triethylamine in dichloromethane T=0 - 20°C; 1 h;
参考文献
Abdul-Hay, Samer; Schiefer, Isaac T.; Chandrasena, R. Esala P.; Li, Min; Abdelhamid, Ramy; Wang, Yue-Ting; Tavassoli, Ehsan; Michalsen, Bradley; Asghodom, Rezene T.; Luo, Jia; Thatcher, Gregory R. J.
ACS Medicinal Chemistry Letters, 2011 , vol. 2, # 9 p. 656 - 661
反应条件
triethylamine in toluene T=-10°C; 2 h;
参考文献
ARCA DISCOVERY, INC.; BRISTOW, Michael, R.; PORT, Jonathan, D.
Patent: WO2010/14263 A1, 2010 ;
Location in patent: Page/Page column 54 ;
WO 2010/014263 A1
反应条件
1: (S)-1-chloro-2,3-dihydroxypropane With potassium phosphate in dichloromethane 3 h; Reflux; 2: With triethylamine in dichloromethane T=0°C; 1 h; 3: 3-nitro-benzenesulfonyl chloride in dichloromethane T=0 - 25°C; 1 h;
参考文献
Dittrich, Torsten; Hanekop, Nils; Infed, Nacera; Schmitt, Lutz; Braun, Manfred
Beilstein Journal of Organic Chemistry, 2012 , vol. 8, p. 1700 - 1704
反应条件
triethylamine in toluene T=-10°C; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Journal of Organic Chemistry, , vol. 54, # 6 p. 1295 - 1304
反应条件
potassium carbonate in butanone 18 h; Heating / reflux;
参考文献
ARTESIAN THERAPEUTICS, INC.
Patent: WO2006/60122 A2, 2006 ;
Location in patent: Page/Page column 37-38 ;
WO 2006/060122 A2
反应条件
1: 3-chloro-2-cyanophenol With potassium carbonate in acetone 0.5 h; Reflux; 2: (R)-(-)-3-nitro-benzenesulfonic acid oxiranylmethyl ester in acetone T=20°C; Reflux;
参考文献
Johansson, Henrik; Cailly, Thomas; Thomsen, Alex Rojas Bie; Braeuner-Osborne, Hans; Pedersen, Daniel Sejer
Beilstein Journal of Organic Chemistry, 2013 , vol. 9, p. 1383 - 1387
反应条件
1: (S)-(+)-3-nitro-benzenesulfonic acid oxiranylmethyl ester; O-allyl-catechol With potassium carbonate; cesium fluoride in N,N-dimethyl-formamide T=25°C; Etherification; 2: isopropylamine T=5°C; Addition; ring cleavage;
参考文献
Kitaori, Kazuhiro; Furukawa, Yoshiro; Yoshimoto, Hiroshi; Otera, Junzo
Tetrahedron, 1999 , vol. 55, # 50 p. 14381 - 14390
反应条件
1: 2-(4-hydroxyphenyl)acetamide; (S)-(+)-3-nitro-benzenesulfonic acid oxiranylmethyl ester With potassium carbonate; cesium fluoride in N,N-dimethyl-formamide T=25°C; Etherification; 24 h; 2: isopropylamine T=5°C; Addition; ring cleavage; 6 h;
参考文献
Kitaori, Kazuhiro; Furukawa, Yoshiro; Yoshimoto, Hiroshi; Otera, Junzo
Tetrahedron, 1999 , vol. 55, # 50 p. 14381 - 14390
参考文献
Applied Research Systems ARS Holding N.V.
Patent: EP1094063 A1, 2001 ;
反应条件
1: phenol With sodium hydride in N,N-dimethyl-formamide T=0 - 20°C; 0.333333 h; 2: (S)-(+)-3-nitro-benzenesulfonic acid oxiranylmethyl ester in N,N-dimethyl-formamide T=0 - 20°C; 16 h;
参考文献
ARTESIAN THERAPEUTICS, INC.
Patent: WO2006/60122 A2, 2006 ;
Location in patent: Page/Page column 26 ;
WO 2006/060122 A2
