(3beta)-雄甾-5,16-二烯-3,17-二醇 3-乙酸酯 17-(三氟甲烷磺酸酯)合成路线 （共 13 条）
反应条件
triethylamine in dichloromethane T=0 - 20°C;
参考文献
WO2012/83112 A2, ;
Page/Page column 181-182 ;
WO 2012/083112 A2
反应条件
2,6-di-tert-butyl-4-methylpyridine in dichloromethane 12 h;
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 13 p. 2463 - 2471
反应条件
1: in 2,4-dimethylbutane 0.25 h; 2: With triethylamine in 2,4-dimethylbutane 2 h; Product distribution / selectivity;
参考文献
WO2006/21776 A1, ;
Page/Page column 17-20 ;
反应条件
1: in dichloromethane 0.25 h; 2: With pyridine in dichloromethane 2 h; Product distribution / selectivity;
参考文献
WO2006/21776 A1, ;
Page/Page column 17-20 ;
反应条件
1: boron trifluoride diethyl etherate / dichloromethane / 4.25 h / 25 °C 2: triethylamine / dichloromethane / 0 - 20 °C View Scheme
参考文献
WO2012/83112 A2, ;
WO 2012/083112 A2
反应条件
tetrakis(triphenylphosphine) palladium(0); triethylamine in dimethyl sulfoxide T=60°C; 4 h;
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 22 p. 4266 - 4277
反应条件
tetrakis(triphenylphosphine) palladium(0); triethylamine in dimethyl sulfoxide T=60°C; 4 h;
参考文献
Journal fuer Praktische Chemie/Chemiker-Zeitung, , vol. 335, # 5 p. 439 - 444
反应条件
potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in 1,4-dioxane; water T=80°C; Suzuki Coupling; 1 h; Inert atmosphere;
参考文献
WO2012/83112 A2, ;
Page/Page column 223-224 ;
WO 2012/083112 A2
反应条件
sodium carbonate in tetrahydrofuran; bis(triphenylphosphine)palladium(II)-chloride
反应条件
sodium carbonate; bis-triphenylphosphine-palladium(II) chloride in tetrahydrofuran; water T=80°C; 5 h;
参考文献
WO2006/21776 A1, ;
Page/Page column 9-11 ;
