乙基5-羟基-1-环戊烯-1-羧酸酯合成路线 （共 11 条）
反应条件
Lipase PS; tert-butyl methyl ether 96 h; Ambient temperature;
参考文献
Forro, Eniko; Galla, Zsolt; Fueloep, Ferenc
Journal of Molecular Catalysis B: Enzymatic, 2013 , vol. 98, p. 92 - 97
反应条件
Candida antarctica lipase B; water in tert-butyl methyl ether T=30°C; 6 h; Resolution of racemateEnzymatic reaction; enantioselective reaction;
参考文献
Forro, Eniko; Galla, Zsolt; Fueloep, Ferenc
Journal of Molecular Catalysis B: Enzymatic, 2013 , vol. 98, p. 92 - 97
反应条件
vinyl acetate; lipase in tert-butyl methyl ester T=20°C; 72 h; Resolution of racemateEnzymatic reaction;
参考文献
Candish, Lisa; Lupton, David W.
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 23 p. 8182 - 8189
反应条件
1: vinyl acetate; ethyl (±)-5-hydroxycyclopent-1-enecarboxylate With Candida antarctica lipase B; water in tert-butyl methyl ether T=30°C; 1 h; Resolution of racemateEnzymatic reaction; 2: diazomethane enantioselective reaction;
参考文献
Forro, Eniko; Galla, Zsolt; Fueloep, Ferenc
Journal of Molecular Catalysis B: Enzymatic, 2013 , vol. 98, p. 92 - 97
反应条件
1: 2,5-dimethoxy-tetrahydrofuran With hydrogenchloride; water
T=70°C; 2.5 h;
2: diethoxyphosphoryl-acetic acid ethyl ester With potassium carbonate; potassium hydrogencarbonate in water
T=20°C; 24 h;
参考文献
Candish, Lisa; Lupton, David W.
Organic Letters, 2010 , vol. 12, # 21 p. 4836 - 4839
反应条件
1: 2,5-dimethoxy-tetrahydrofuran With hydrogenchloride in water
T=70°C; 2.5 h;
2: (EtO)2POCH2CO2Et With potassium carbonate in water
T=20°C; 36 h;
参考文献
Candish, Lisa; Lupton, David W.
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 23 p. 8182 - 8189
反应条件
potassium carbonate in water
Ambient temperature; Yield given;
参考文献
Graff, M.; Dilaimi, A. Al; Seguineau, P.; Rambaud, M.; Villieras, J.
Tetrahedron Letters, 1986 , vol. 27, # 14 p. 1577 - 1578
反应条件
1: bromine / CCl4 / 3 h / 0 - 5 °C
2: 89 percent / t-BuOK / tetrahydrofuran / -40 - -30 °C
3: 72 percent / K2CO3 / methanol / Ambient temperature
4: POCl3 / CH2Cl2
5: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 1 h
View Scheme
参考文献
Danikiewicz, Witold; Jaworski, Tadeusz; Kwiatkowski, Stefan
Synthetic Communications, 1983 , vol. 13, # 3 p. 255 - 264
反应条件
1: POCl3 / CH2Cl2
2: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 1 h
View Scheme
参考文献
Danikiewicz, Witold; Jaworski, Tadeusz; Kwiatkowski, Stefan
Synthetic Communications, 1983 , vol. 13, # 3 p. 255 - 264
反应条件
water; potassium carbonate
Yield given;
参考文献
Amri, H.; Villieras, J.
Tetrahedron Letters, 1987 , vol. 28, # 45 p. 5521 - 5524
