1: 1) BuLi / 1) THF, hexane, 0 deg C, 15 min, 2) HMPA, RT, 24h 2: 81 percent / i-BuMgBr / Cp2TiCl2 / diethyl ether / 12 h / 26 - 28 °C 3: oxalic acid, 2,5-di-tert-butylhydroquinone / acetone; H2O / 2 h / Heating 4: 1) n-BuLi / 1) THF, hexane, -60 deg C, 1h, 2) 0 deg C, 1h View Scheme

1: 81 percent / i-BuMgBr / Cp2TiCl2 / diethyl ether / 12 h / 26 - 28 °C 2: oxalic acid, 2,5-di-tert-butylhydroquinone / acetone; H2O / 2 h / Heating 3: 1) n-BuLi / 1) THF, hexane, -60 deg C, 1h, 2) 0 deg C, 1h View Scheme

1: oxalic acid, 2,5-di-tert-butylhydroquinone / acetone; H2O / 2 h / Heating 2: 1) n-BuLi / 1) THF, hexane, -60 deg C, 1h, 2) 0 deg C, 1h View Scheme

1: diethyl ether / -30 - 20 °C 2: 79 percent / Na<AlH2(OCH2CH2OCH3)2> / toluene; diethyl ether / Heating View Scheme

1: diethyl ether / -30 - 20 °C 2: 79 percent / Na<AlH2(OCH2CH2OCH3)2> / toluene; diethyl ether / Heating View Scheme

n-butyllithium 1) THF, hexane, -60 deg C, 1h, 2) 0 deg C, 1h; Yield given. Multistep reaction;

1: 44 percent / t-BuOOH, Ti(O-i-Pr)4, L-(+)-DIPT, molecular sieves 4 Angstroem / CH2Cl2 / 4 h / -21 °C 2: 86 percent / t-BuOOH, d-(-)-DIPT, Ti(O-i-Pr)4, molecular sieves 4 Angstroem / CH2Cl2 / 4 h / -21 °C 3: imidazole / dimethylformamide / Ambient temperature 4: 1) Bu3SnLi, 2) I2 / 1) THF, 0 deg C, 3h, 2) Et2O, 0 deg C, 0.5h 5: 1) disiamylborane, 2) LiOH / 2) Pd(PPh3)4 / 1) THF, 0 deg C, 1h, 2) 40 deg C, 18h 6: 85 percent / n-Bu4NF / tetrahydrofuran / 17 h / Ambient temperature View Scheme