tetrabutyl ammonium fluoride in tetrahydrofuran 17 h; Ambient temperature;

Multi-step reaction with 4 steps 1: imidazole / dimethylformamide / 0 - 20 °C2: 94 percent / Pd(PPh3)4, CuI, nPrNH2 / benzene / 20 °C3: 90 percent / KCN, AgNO3, / ethanol; tetrahydrofuran; H2O / 0 °C4: 1.) disiamylborane, 2.) aq. 2N NaOH, Pd(PPh3)4 / 1.) THF,0 deg C, 1h; 2.) 50 deg C, 16 h  

Multi-step reaction with 3 steps 1: 94 percent / Pd(PPh3)4, CuI, nPrNH2 / benzene / 20 °C2: 90 percent / KCN, AgNO3, / ethanol; tetrahydrofuran; H2O / 0 °C3: 1.) disiamylborane, 2.) aq. 2N NaOH, Pd(PPh3)4 / 1.) THF,0 deg C, 1h; 2.) 50 deg C, 16 h  

Multi-step reaction with 4 steps 1: TBHP, D(-)DIPT,Ti(OiPr)4, 3A molecular sieves / CH2Cl2 / 3 h / -21 °C2: imidazole / dimethylformamide3: 1.) nBu3SnH, LDA, 2.) I2 / 1.) THF, 0 deg C, 3 h; 2.) Et2O, 0 deg C, 30 min4: 1.) disiamylborane, 2.) aq. 2N NaOH, Pd(PPh3)4 / 1.) THF,0 deg C, 1h; 2.) 50 deg C, 16 h  

Multi-step reaction with 6 steps 1: Br2 / CH2Cl2 / 0 °C2: nBu4NF / tetrahydrofuran / 0 °C3: imidazole / dimethylformamide / 0 - 20 °C4: 94 percent / Pd(PPh3)4, CuI, nPrNH2 / benzene / 20 °C5: 90 percent / KCN, AgNO3, / ethanol; tetrahydrofuran; H2O / 0 °C6: 1.) disiamylborane, 2.) aq. 2N NaOH, Pd(PPh3)4 / 1.) THF,0 deg C, 1h; 2.) 50 deg C, 16 h  

Multi-step reaction with 3 steps 1: imidazole / dimethylformamide2: 1.) nBu3SnH, LDA, 2.) I2 / 1.) THF, 0 deg C, 3 h; 2.) Et2O, 0 deg C, 30 min3: 1.) disiamylborane, 2.) aq. 2N NaOH, Pd(PPh3)4 / 1.) THF,0 deg C, 1h; 2.) 50 deg C, 16 h