1: 99.4 percent / 1N aq. NaOH / methanol / 1 h / Ambient temperature 2: 63 percent / N,N-dicyclohexylcarbodimide / dioxane / 4 h / Ambient temperature 3: 24 percent / 1N aq. NaOH / methanol; acetonitrile / 0.5 h / Ambient temperature 4: 6.1 mg / H2 / 5percent Pd/C / methanol / 3 h / Ambient temperature 5: 39 percent / N,N-dicyclohexylcarbodimide / dioxane / 15 h 6: 60 percent / AlCl3 / CH2Cl2 / 2 h / Ambient temperature View Scheme

1: 99.4 percent / 1N aq. NaOH / methanol / 1 h / Ambient temperature 2: 63 percent / N,N-dicyclohexylcarbodimide / dioxane / 4 h / Ambient temperature 3: 24 percent / 1N aq. NaOH / methanol; acetonitrile / 0.5 h / Ambient temperature 4: 6.1 mg / H2 / 5percent Pd/C / methanol / 3 h / Ambient temperature 5: 39 percent / N,N-dicyclohexylcarbodimide / dioxane / 15 h View Scheme

With  sodium hydroxide in  methanol 1 h;  Ambient temperature;   

Multi-step reaction with 5 steps 1: 100 percent / methanol; diethyl ether / 5 h / Ambient temperature2: 91.2 percent / H2, HCl / 5percent Pd/C / methanol / Ambient temperature3: 94.7 percent / N,N-dicyclohexylcarbodimide, Et3N / CH2Cl2 / 12 h / Ambient temperature4: 97.9 percent / H2, HCl / 5percent Pd/C / methanol / Ambient temperature5: 97.8 percent / N,N-dicyclohexylcarbodimide, N-hydroxybenzotriazole, Et3N / CH2Cl2 / 12 h / Ambient temperature  

Multi-step reaction with 4 steps 1: 91.2 percent / H2, HCl / 5percent Pd/C / methanol / Ambient temperature2: 94.7 percent / N,N-dicyclohexylcarbodimide, Et3N / CH2Cl2 / 12 h / Ambient temperature3: 97.9 percent / H2, HCl / 5percent Pd/C / methanol / Ambient temperature4: 97.8 percent / N,N-dicyclohexylcarbodimide, N-hydroxybenzotriazole, Et3N / CH2Cl2 / 12 h / Ambient temperature  

Multi-step reaction with 2 steps 1: 97.9 percent / H2, HCl / 5percent Pd/C / methanol / Ambient temperature2: 97.8 percent / N,N-dicyclohexylcarbodimide, N-hydroxybenzotriazole, Et3N / CH2Cl2 / 12 h / Ambient temperature