5,6,7,7a-四氢噻吩并[3,2-c]吡啶-2(4H)-酮盐酸盐合成路线 （共 9 条）
反应条件
hydrogenchloride in water; acetone T=25 - 50°C; 1 h;
参考文献
MAYUKA LABS PVT. LTD.; KRISHNAMURTHY, Chandra, Sekhar, Nakka; SINGH, Jagat; KHAN, Mohd, Yunus
Patent: WO2012/1486 A1, 2012 ;
Location in patent: Page/Page column 20 ;
反应条件
1.1: triethylamine / dichloromethane / 9 h / 0 - 5 °C 2.1: n-butyllithium / tetrahydrofuran / 1 h / 0 - 15 °C / Inert atmosphere 2.2: 1 h / 0 - 15 °C / Inert atmosphere 2.3: 2 h / 0 - 30 °C 3.1: hydrogenchloride; water / acetone / 3 h / 25 - 30 °C View Scheme
反应条件
1.1: n-butyllithium / tetrahydrofuran / 1 h / 0 - 15 °C / Inert atmosphere 1.2: 1 h / 0 - 15 °C / Inert atmosphere 1.3: 2 h / 0 - 30 °C 2.1: hydrogenchloride; water / acetone / 3 h / 25 - 30 °C View Scheme
反应条件
1.1: dichloromethane / 40 - 45 °C 1.2: 20 - 70 °C 2.1: triethylamine / dichloromethane / 12 - 28 °C 3.1: n-butyllithium / toluene; hexane; tetrahydrofuran / -5 - 10 °C 3.2: -5 - 10 °C 4.1: hydrogenchloride / water; acetone / 1 h / 25 - 50 °C View Scheme
反应条件
1: 5,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2(4H)-one hydrochloride With potassium carbonate in acetonitrile T=25 - 30°C; 0.5 h; 2: α-cyclopropylcarbonyl-2-fluorobenzyl bromide in acetonitrile T=25 - 30°C; 6 h; 3: acetic anhydride With triethylamine in acetonitrile T=0 - 30°C; 6.5 h;
参考文献
WO2011/42918 A2, ;
Page/Page column 48-49 ;
反应条件
1: With potassium carbonate in acetonitrile T=25 - 30°C; 6.5 h; 2: With acetic anhydride; triethylamine in acetonitrile T=0 - 30°C; 6.5 h; 3: With water in acetonitrile
参考文献
US2012/202066 A1, ;
Page/Page column 22-23 ;
反应条件
1.1: potassium carbonate / acetonitrile / 0.5 h / 25 - 30 °C 1.2: 7 h / 25 - 30 °C 2.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 3.33 h / 10 - 30 °C View Scheme
反应条件
ammonium hydrogen carbonate in dichloromethane T=5 - 20°C;
参考文献
MAYUKA LABS PVT. LTD.; KRISHNAMURTHY, Chandra, Sekhar, Nakka; SINGH, Jagat; KHAN, Mohd, Yunus
Patent: WO2012/1486 A1, 2012 ;
Location in patent: Page/Page column 22 ;
反应条件
1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere 2: triethylamine / dichloromethane / 20 °C / Inert atmosphere 3: hydrogenchloride; water / ethyl acetate / 20 °C View Scheme
参考文献
MAYUKA LABS PVT. LTD.; KRISHNAMURTHY, Chandra, Sekhar, Nakka; SINGH, Jagat; KHAN, Mohd, Yunus
Patent: WO2012/1486 A1, 2012 ;
