1: 2-bromo-5-chloro-aniline With anhydrous iron chloride; zinc(II) chloride in ethanol; water T=50°C; 2: acrolein in ethanol; water T=80°C; 27 h; 3: With sodium hydroxide in ethanol; dichloromethane; water
1: 2-bromo-5-chloro-aniline With anhydrous iron chloride; zinc(II) chloride in ethanol; water
T=50°C;
2: acrolein in ethanol; water
T=80°C; 27 h;
3: With sodium hydroxide in ethanol; dichloromethane; water
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GmbH
Patent: WO2009/62285 A1, 2009 ;
Location in patent: Page/Page column 91-92 ;
