4-氯-7-{5-O-[二甲基(2-甲基-2-丙基)硅烷基]-2,3-O-异亚丙基呋喃戊糖基}-7H-吡咯并[2,3-d]嘧啶合成路线 （共 6 条）
反应条件
sodium hydride in acetonitrile 1 h; Ambient temperature;
参考文献
Ramasamy; Imamura; Robins; Revankar
Tetrahedron Letters, 1987 , vol. 28, # 43 p. 5107 - 5110
反应条件
potassium hydroxide; tri[2-(2-methoxyethoxy)ethyl]amine in tetrahydrofuran; acetonitrile T=0 - 20°C;
参考文献
Journal of Medicinal Chemistry, , vol. 51, # 13 p. 3934 - 3945
反应条件
1: CCl4, tris(dimethylamino)phosphane / tetrahydrofuran / 2 h / -78 °C 2: 65 percent / KOH / tris<2-(2-methoxyethoxy)ethyl>amine / acetonitrile; tetrahydrofuran / 20 h View Scheme
参考文献
Helvetica Chimica Acta, , vol. 71, # 6 p. 1573 - 1585
反应条件
tri[2-(2-methoxyethoxy)ethyl]amine; potassium hydroxide in tetrahydrofuran; acetonitrile
参考文献
Journal of Medicinal Chemistry, , vol. 53, # 1 p. 460 - 470
反应条件
1: 89 percent / 90percent aq.CF3COOH / 1 h / Ambient temperature 2: 82 percent / NH3 / methanol / 24 h / 50 °C View Scheme
参考文献
Ramasamy; Imamura; Robins; Revankar
Tetrahedron Letters, 1987 , vol. 28, # 43 p. 5107 - 5110
反应条件
trifluoroacetic acid in water 1 h; Ambient temperature;
参考文献
Ramasamy; Imamura; Robins; Revankar
Journal of Heterocyclic Chemistry, 1988 , vol. 25, # 6 p. 1893 - 1898
