n-butyllithium; sodium carbonate; (2,2-Me2-propyl)-((R)-1-phenyl-2-piperidin-1-yl-ethyl)-amine; lithium chloride 1.) THF, hexane, -78 deg C, 2.5 h; -78 deg C, 30 min, 2.) EtOH, reflux, 1 h; Yield given. Multistep reaction;

1: 1.) n-BuLi, LiCl, (2R)-5,5-dimethyl-2-phenyl-1-(N-piperidinyl)-3-azahexane, 2.) Na2CO3 / 1.) THF, hexane, -78 deg C, 2.5 h; -78 deg C, 30 min, 2.) EtOH, reflux, 1 h 2: CuBr2 / ethyl acetate / 30 h / Heating View Scheme