反应条件
1: 4-(dimethylamino)pyridine (DMAP) / acetonitrile / 0.08 h / Ambient temperature
2: Bu3SnH, 2,2'-azobis(isobutyronitrile) / toluene / 1 h / 100 °C / radical deoxygenation
3: 88 percent / tetrabutylammonium fluoride (TBAF) / tetrahydrofuran / 0.17 h / Ambient temperature
4: methanolic ammonia / 48 h / 100 °C
View Scheme
参考文献
Matsuda; Takenuki; Sasaki; Ueda
Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 234 - 239