N-苄氧羰基-L-谷氨酸合成路线 （共 80 条）
反应条件
1.1: 78 percent / hydrogen / Pd/C / ethanol / 12 h / 20 °C / atmospheric pressure 2.1: 86 percent / iPr2NEt / CH2Cl2 / 15 h / 20 °C 3.1: 95 percent / CF3COOH / methanol; H2O / 15 h / 20 °C 4.1: NaIO4 / methanol / 3 h / 20 °C 4.2: Jones' reagent / acetone / 4 h / 0 °C View Scheme
参考文献
European Journal of Organic Chemistry, , # 13 p. 2114 - 2120
反应条件
1: 87 percent / triethylamine / CHCl3 / 1 h / 20 °C 2: 70 percent / triethylamine / aq. methanol / 1 h / 20 °C View Scheme
参考文献
Chemistry Letters, , # 1 p. 66 - 67
反应条件
1: With 1,1-dimethylethylmagnesium chloride in tetrahydrofuran T=-78°C; 4 h; 2: With citric acid in tetrahydrofuran
参考文献
Tetrahedron Asymmetry, , vol. 17, # 14 p. 2120 - 2125
反应条件
1.1: 86 percent / iPr2NEt / CH2Cl2 / 15 h / 20 °C 2.1: 95 percent / CF3COOH / methanol; H2O / 15 h / 20 °C 3.1: NaIO4 / methanol / 3 h / 20 °C 3.2: Jones' reagent / acetone / 4 h / 0 °C View Scheme
参考文献
European Journal of Organic Chemistry, , # 13 p. 2114 - 2120
反应条件
1.1: 95 percent / CF3COOH / methanol; H2O / 15 h / 20 °C 2.1: NaIO4 / methanol / 3 h / 20 °C 2.2: Jones' reagent / acetone / 4 h / 0 °C View Scheme
参考文献
European Journal of Organic Chemistry, , # 13 p. 2114 - 2120
反应条件
1: With Barlos chlorotrityl resin 2: With sodium trimethyl-silanolate in tetrahydrofuran 24 h; 3: With scavenger TIPS; trifluoroacetic acid in tetrahydrofuran; dichloromethane
参考文献
Tetrahedron Letters, , vol. 46, # 11 p. 1795 - 1797
反应条件
1: thien-2-yl bromide With magnesium in tetrahydrofuran T=40°C; 2 h; 2: benzyl 2,6-dioxotetrahydro-2H-pyran-3-ylcarbamate in tetrahydrofuran T=-78°C; 4 h; 3: With citric acid in tetrahydrofuran T=-78 - 20°C; Title compound not separated from byproducts;
参考文献
Tetrahedron Asymmetry, , vol. 17, # 14 p. 2120 - 2125
反应条件
1: 1-bromo-butane With magnesium in tetrahydrofuran T=40°C; 2 h; 2: benzyl 2,6-dioxotetrahydro-2H-pyran-3-ylcarbamate in tetrahydrofuran T=-78°C; 4 h; 3: With citric acid in tetrahydrofuran T=-78 - 20°C; Title compound not separated from byproducts;
参考文献
Tetrahedron Asymmetry, , vol. 17, # 14 p. 2120 - 2125
反应条件
1: 3-methoxybromobenzene With magnesium in tetrahydrofuran T=40°C; 2 h; 2: benzyl 2,6-dioxotetrahydro-2H-pyran-3-ylcarbamate in tetrahydrofuran T=-78°C; 4 h; 3: With citric acid in tetrahydrofuran T=-78 - 20°C; Title compound not separated from byproducts;
参考文献
Tetrahedron Asymmetry, , vol. 17, # 14 p. 2120 - 2125
反应条件
1: 1-bromo-hexane With magnesium in tetrahydrofuran T=40°C; 2 h; 2: benzyl 2,6-dioxotetrahydro-2H-pyran-3-ylcarbamate in tetrahydrofuran T=-78°C; 4 h; 3: With citric acid in tetrahydrofuran T=-78 - 20°C; Title compound not separated from byproducts;
参考文献
Tetrahedron Asymmetry, , vol. 17, # 14 p. 2120 - 2125
