N-苄氧羰基-L-谷氨酸合成路线 （共 80 条）
反应条件
1: sulfinyl chloride / benzene / 3 h / 50 °C
2: aq. NaOH / diethyl ether; dioxane / 1.) 0 deg C, 30 min, 2.) rt, 30 min
View Scheme
参考文献
Ide; Tanaka; Koga; Yagishita
Agricultural and Biological Chemistry, 1982 , vol. 46, # 6 p. 1679 - 1680
反应条件
1: 98 percent / BF3*OEt2
2: 79 percent / LiBH4 / methanol; tetrahydrofuran / 4 h / 0 °C
View Scheme
参考文献
Truchot, Cyrille; Sasaki, N. Andre
Heterocycles, 2004 , vol. 64, p. 393 - 406
反应条件
1: acetic acid anhydride
2: 120 - 130 °C
View Scheme
参考文献
Le Quesne; Young
Journal of the Chemical Society, 1950 , p. 1954,1958
参考文献
Nefkens,G.H.L.; Nivard,R.J.F.
Recueil des Travaux Chimiques des Pays-Bas, 1964 , vol. 83, p. 199 - 207
反应条件
1: (2S)-2-[(Phenylmethoxy)carbonyl]aminoglutaric acid With acetic anhydride
T=45°C;
2: methanol Heating;
3: N,N-dicyclohexylamine Further stages.;
参考文献
Manturewicz; Grzonka
Polish Journal of Chemistry, 2007 , vol. 81, # 12 p. 2121 - 2131
反应条件
1: acetic acid anhydride
2: ethyl acetate; KHCO3; H2O
3: aqueous NaOH
4: palladium; methanol / Hydrogenation
View Scheme
参考文献
Le Quesne; Young
Journal of the Chemical Society, 1950 , p. 1954,1958
反应条件
1: 90 percent / toluenesulfonic acid / toluene / 3 h / Heating
2: thionyl chloride / CH2Cl2 / 0.5 h / Heating
3: pyridine / CH2Cl2 / 0.25 h / 20 °C
4: lithium hydroxide / tetrahydrofuran; H2O / 0.5 h / 5 °C
5: hydrogen / Pd/C / methanol
View Scheme
参考文献
Esslinger, C. Sean; Cybulski, Kimberly A.; Rhoderick, Joseph F.
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 4 p. 1111 - 1118
反应条件
ammonium hydroxide in water
5 h; Ambient temperature;
参考文献
Lee; Kim; Ko
Synthesis, 1991 , # 11 p. 935 - 936
反应条件
tetrahydrofuran
T=-35 - -20°C; anschliessendes Einleiten von NH3;
参考文献
Ressler,C.
Journal of the American Chemical Society, 1960 , vol. 82, p. 1641 - 1644
反应条件
acetic anhydride
T=55°C; 0.5 h;
参考文献
Manesis, Nick J.; Goodman, Murray
Journal of Organic Chemistry, 1987 , vol. 52, # 24 p. 5331 - 5341
