N6-Cbz-L-赖氨酸合成路线 （共 62 条）
反应条件
1: water; oxygen; catalase / 37 °C / Reagens 4: aus Klapperschlangengift hergestelltes L-Aminosaeure:Sauerstoff-Oxidoreduktase-Praeparat; bei pH 7,2 2: HBr; acetic acid View Scheme
参考文献
Meister
Journal of Biological Chemistry, 1954 , vol. 206, p. 577,582
反应条件
1: N6-[(phenylmethoxy)carbonyl]-L-lysine With sodium hydrogencarbonate in tetrahydrofuran; water 2: (9H-Fluoren-9-yl)-methyl chloroformate in tetrahydrofuran; water T=0°C; 3: With hydrogenchloride in tetrahydrofuran; water pH=2 - 3;
参考文献
Huhtiniemi, Tero; Salo, Heikki S.; Suuronen, Tiina; Poso, Antti; Salminen, Antero; Leppaenen, Jukka; Jarho, Elina; Lahtela-Kakkonen, Maija
Journal of Medicinal Chemistry, 2011 , vol. 54, # 19 p. 6456 - 6468
反应条件
sodium hydrogencarbonate in water; acetone Ambient temperature;
参考文献
Schoen, Istvan; Kisfaludy, Lajos
Synthesis, 1986 , # 4 p. 303 - 305
参考文献
Kisfaludy, Lajos; Schoen, Istvan
Synthesis, 1983 , # 4 p. 325 - 327
反应条件
1: 77 percent / SOCl2 / 1 h / 1.) 0 deg C, 1 h, 2.) RT, 20 h 2: 77 percent / NH3 / methanol / 192 h / Ambient temperature View Scheme
参考文献
Beck-Piotraschke, Karin; Jakubke, Hans-Dieter
Tetrahedron Asymmetry, 1998 , vol. 9, # 9 p. 1505 - 1518
反应条件
hydrogenchloride; sodium hydroxide; N2; toluene-4-sulfonic acid; benzyl alcohol in water; toluene
参考文献
Cytogen Corporation
Patent: US1312 H1, 1994 ;
反应条件
1: T=20 - 90°C; 2: With sodium carbonate in water pH=10; 3: With hydrogenchloride in diethyl ether
参考文献
Wu, Jianhui; Li, Chunyu; Zhao, Ming; Wang, Wenjing; Wang, Yuji; Peng, Shiqi
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 17 p. 6220 - 6229
反应条件
1: 89 percent / aq. NaOH / 2-methyl-propan-2-ol / Ambient temperature 2: H2 / 5percent Pd/C / methanol; H2O / 24 h / 2585.7 Torr View Scheme
参考文献
Acosta, C. Kirk; Bahr, Martin L.; Burdett, James E.; Cessac, James W.; Martinez, Rudy A.; et al.
Journal of Chemical Research, Miniprint, 1991 , # 5 p. 914 - 934
反应条件
(i) aq. NaOH, dioxane, (ii) H2, Pd-C, aq. MeOH; Multistep reaction;
参考文献
Schwyzer,R. et al.
Helvetica Chimica Acta, 1963 , vol. 46, p. 870 - 889
反应条件
1: NaOH / H2O / 0 - 50 °C 2: H2 / Pd-on-charcoal / methanol; H2O / 2 h / 20 °C / 760.05 Torr View Scheme
参考文献
Liu, Cuihua; Hudson, Robert H. E.; Petersen, Nils O.
Synthesis, 2002 , # 10 p. 1398 - 1406
