2-((4-溴噻唑-2-基)甲基)异吲哚啉-1,3-二酮合成路线 （共 2 条）
反应条件
18-crown-6 ether in 1,4-dioxane 22 h; Reflux;
参考文献
MERCK SHARP and DOHME CORP.; MACHACEK, Michelle, R.; AHEARN, Sean, P.; ROMEO, Eric; SIU, Tony; CHICHETTI, Stephanie; DE ALMEIDA, Gabriela
Patent: WO2011/37780 A1, 2011 ;
Location in patent: Page/Page column 55-56 ;
WO 2011/037780 A1
反应条件
ethanol; hydrazine hydrate
24 h; Reflux;
参考文献
MERCK SHARP and DOHME CORP.; MACHACEK, Michelle, R.; AHEARN, Sean, P.; ROMEO, Eric; SIU, Tony; CHICHETTI, Stephanie; DE ALMEIDA, Gabriela
Patent: WO2011/37780 A1, 2011 ;
Location in patent: Page/Page column 55-57 ;
WO 2011/037780 A1
