反应条件
1.1: aq. HBr; sodium nitrite / dioxane / 2 h / 0 °C
1.2: aq. HBr; copper(I) bromide / 0.33 h / 50 °C
2.1: aq. potassium fluoride; tris(dibenzylideneacetone)dipalladium(0); tri-tert-butylphosphine / dioxane / 2.25 h / 20 - 50 °C
3.1: SnCl2*2H2O / ethanol; tetrahydrofuran / 24 h / 20 °C
4.1: aq. HBr; sodium nitrite / dioxane / 1 h / 0 °C
4.2: 10.9 g / aq. HBr; copper(I) bromide / 0 - 50 °C
View Scheme
参考文献
Russell, Michael G. N.; Carling, Robert W.; Street, Leslie J.; Hallett, David J.; Goodacre, Simon; Mezzogori, Elena; Reader, Michael; Cook, Susan M.; Bromidge, Frances A.; Newman, Robert; Smith, Alison J.; Wafford, Keith A.; Marshall, George R.; Reynolds, David S.; Dias, Rebecca; Ferris, Pushpindar; Stanley, Jo; Lincoln, Rachael; Tye, Spencer J.; Sheppard, Wayne F. A.; Sohal, Bindi; Pike, Andrew; Dominguez, Maria; Atack, John R.; Castro, Jose L.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 4 p. 1235 - 1238