4-[[(2S)-5-氨基-1-[[(2S)-3-甲基-1-[[(2S)-3-甲基-1-[[(2S)-1-[[(2S)-2-[(4-硝基苯基)氨基]丙酰]氨基]-1-氧代丙烷-2-基]氨基]-1-氧代丁烷-2-基]氨基]-1-氧代丁烷-2-基]氨基]-1,5-二氧代戊烷-2-基]氨基]-4-氧代丁酸合成路线 （共 10 条）
反应条件
pyridine; triethylamine
T=4°C;
参考文献
Okada; Teno; Tsuboi; Nakabayashi; Itoh; Okamoto; Nishi
Chemical and pharmaceutical bulletin, 1988 , vol. 36, # 6 p. 1982 - 1989
反应条件
pyridine; triethylamine in N,N-dimethyl-formamide
Ambient temperature;
参考文献
Iguchi, Shin; Hirano, Kenichi; Okamoto, Hiroshi; Okamoto, Yoshiko; Okada, Yoshio
Chemical and Pharmaceutical Bulletin, 1996 , vol. 44, # 8 p. 1599 - 1602
反应条件
1: 78.9 percent / triethylamine / dimethylformamide / Ambient temperature
2: hydrogen bromide / acetic acid
3: 66.5 percent / pyridine, triethylamine / 4 °C
View Scheme
参考文献
Okada; Teno; Tsuboi; Nakabayashi; Itoh; Okamoto; Nishi
Chemical and pharmaceutical bulletin, 1988 , vol. 36, # 6 p. 1982 - 1989
反应条件
2: 55.1 percent / triethylamine / dimethylformamide; tetrahydrofuran / 4 °C
3: hydrogen bromide / acetic acid
4: 78.9 percent / triethylamine / dimethylformamide / Ambient temperature
5: hydrogen bromide / acetic acid
6: 66.5 percent / pyridine, triethylamine / 4 °C
View Scheme
参考文献
Okada; Teno; Tsuboi; Nakabayashi; Itoh; Okamoto; Nishi
Chemical and pharmaceutical bulletin, 1988 , vol. 36, # 6 p. 1982 - 1989
反应条件
1: 80.2 percent / triethylamine / dimethylformamide; dioxane / 4 °C
2: hydrogen bromide / acetic acid
3: 55.1 percent / triethylamine / dimethylformamide; tetrahydrofuran / 4 °C
4: hydrogen bromide / acetic acid
5: 78.9 percent / triethylamine / dimethylformamide / Ambient temperature
6: hydrogen bromide / acetic acid
7: 66.5 percent / pyridine, triethylamine / 4 °C
View Scheme
参考文献
Okada; Teno; Tsuboi; Nakabayashi; Itoh; Okamoto; Nishi
Chemical and pharmaceutical bulletin, 1988 , vol. 36, # 6 p. 1982 - 1989
反应条件
1: 55.1 percent / triethylamine / dimethylformamide; tetrahydrofuran / 4 °C
2: hydrogen bromide / acetic acid
3: 78.9 percent / triethylamine / dimethylformamide / Ambient temperature
4: hydrogen bromide / acetic acid
5: 66.5 percent / pyridine, triethylamine / 4 °C
View Scheme
参考文献
Okada; Teno; Tsuboi; Nakabayashi; Itoh; Okamoto; Nishi
Chemical and pharmaceutical bulletin, 1988 , vol. 36, # 6 p. 1982 - 1989
反应条件
1: 80.2 percent / triethylamine / dimethylformamide; dioxane / 4 °C
2: hydrogen bromide / acetic acid
3: 55.1 percent / triethylamine / dimethylformamide; tetrahydrofuran / 4 °C
4: hydrogen bromide / acetic acid
5: 78.9 percent / triethylamine / dimethylformamide / Ambient temperature
6: hydrogen bromide / acetic acid
7: 66.5 percent / pyridine, triethylamine / 4 °C
View Scheme
参考文献
Okada; Teno; Tsuboi; Nakabayashi; Itoh; Okamoto; Nishi
Chemical and pharmaceutical bulletin, 1988 , vol. 36, # 6 p. 1982 - 1989
反应条件
1: 78.9 percent / triethylamine / dimethylformamide / Ambient temperature
2: hydrogen bromide / acetic acid
3: 66.5 percent / pyridine, triethylamine / 4 °C
View Scheme
参考文献
Okada; Teno; Tsuboi; Nakabayashi; Itoh; Okamoto; Nishi
Chemical and pharmaceutical bulletin, 1988 , vol. 36, # 6 p. 1982 - 1989
反应条件
1: hydrogen bromide / acetic acid
2: 55.1 percent / triethylamine / dimethylformamide; tetrahydrofuran / 4 °C
3: hydrogen bromide / acetic acid
4: 78.9 percent / triethylamine / dimethylformamide / Ambient temperature
5: hydrogen bromide / acetic acid
6: 66.5 percent / pyridine, triethylamine / 4 °C
View Scheme
参考文献
Okada; Teno; Tsuboi; Nakabayashi; Itoh; Okamoto; Nishi
Chemical and pharmaceutical bulletin, 1988 , vol. 36, # 6 p. 1982 - 1989
反应条件
1: hydrogen bromide / acetic acid
2: 80.2 percent / triethylamine / dimethylformamide; dioxane / 4 °C
3: hydrogen bromide / acetic acid
4: 55.1 percent / triethylamine / dimethylformamide; tetrahydrofuran / 4 °C
5: hydrogen bromide / acetic acid
6: 78.9 percent / triethylamine / dimethylformamide / Ambient temperature
7: hydrogen bromide / acetic acid
8: 66.5 percent / pyridine, triethylamine / 4 °C
View Scheme
参考文献
Okada; Teno; Tsuboi; Nakabayashi; Itoh; Okamoto; Nishi
Chemical and pharmaceutical bulletin, 1988 , vol. 36, # 6 p. 1982 - 1989
