全-反式-13,14-二氢视黄醇合成路线 (共 5 条)
反应条件
1: With nicotinamide adenine dinucleotide; NADP; adenosine 5'-triphosphoric acid; tri-(hydroxymethyl)-methylamine; [14C]-Sucrose; glycosylation-deficient HEK-293S cells transfected with mouse retinal dehydrogenase type 2 (HEK-RALDH2 cells) T=37°C; pH=8.0; 2 h; Enzymatic reaction; 2: With hydroxylamine in water; acetonitrile T=20°C; pH=7.0; 0.5 h; 3: With ammonium acetate in water pH=4.0; Product distribution / selectivity;
参考文献
US2008/249042 A1, ;
Page/Page column 2; 27; 29; 31; Sheet 13./24; 24/24 ;
反应条件
1: With 18-crown-6 ether; potassium tert-butylate in dichloromethane T=-78 - 20°C; 12 h; 2: With lithium aluminium tetrahydride in diethyl ether T=0°C; 0.5 h; Product distribution / selectivity;
参考文献
US2008/249042 A1, ;
Page/Page column 2; 19; 22; Sheet 22/24 ;
反应条件
tetrabutyl ammonium fluoride 1.) Wittig-reaction; Multistep reaction;
参考文献
Journal of the American Chemical Society, , vol. 110, # 17 p. 5915 - 5917
反应条件
mouse retinol saturase (RetSat) expressed in HEKK cells Enzymatic reaction; Product distribution / selectivity;
参考文献
US2008/249042 A1, ;
Page/Page column 2; 22-23; Sheet 3/24; 4/24; 23/24 ;
反应条件
tetracycline-induced HEKK-mouse retinol saturase (RetSat) cells Enzymatic reaction; Product distribution / selectivity;
参考文献
US2008/249042 A1, ;
Page/Page column 2; 23; Sheet 6/24 ;