2-(6-甲基-4,8-二氧代-1,3,6,2-二氧氮硼杂八环-2-基)-1H-吡咯-1-甲酸叔丁酯合成路线 （共 4 条）
反应条件
1: N-(tert-butyloxycarbonyl)pyrrole With n-butyllithium; tri-isopropoxy-borane; N-ethyl-N,N-diisopropylamine in tetrahydrofuran; hexane T=-78 - 20°C; 2: MIDA in dimethyl sulfoxide T=75°C; P=1 Torr; 2 h;
参考文献
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS; BURKE, Martin, D.; KNAPP, David, M.; GILLIS, Eric, P.
Patent: WO2010/36921 A2, 2010 ;
Location in patent: Page/Page column 38-39 ;
反应条件
in dimethyl sulfoxide; toluene Dean-StarkRefluxInert atmosphereSealed tubeSchlenk technique;
参考文献
Xu, Liang; Ding, Siyi; Li, Pengfei
Angewandte Chemie - International Edition, 2014 , vol. 53, # 7 p. 1822 - 1826
Angew. Chem., 2014 , vol. 126, # 7 p. 1853 - 1857,5
反应条件
sodium hydroxide in tetrahydrofuran; water T=23°C; 0.333333 h;
参考文献
Knapp, David M.; Gillis, Eric P.; Burke, Martin D.
Journal of the American Chemical Society, 2009 , vol. 131, p. 6961 - 6963
反应条件
in not given hydrolysis of appropriate N-methyliminodiacetic acid boronate;
参考文献
Knapp, David M.; Gillis, Eric P.; Burke, Martin D.
Journal of the American Chemical Society, 2009 , vol. 131, p. 6961 - 6963
