5-(3-二甲氨基丙基)-10,11-二氢二苯并[A,D]环庚烯-5-醇合成路线 （共 6 条）
反应条件
1: 1-dimethylamino-3-chloropropane With iodine; magnesium in tetrahydrofuran Heating; 2: 10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-one in tetrahydrofuran T=0 - 20°C; Grignard reaction; Further stages.;
参考文献
Hudgens, Debjani P.; Taylor, Catherine; Batts, Timothy W.; Patel, Manoj K.; Brown, Milton L.
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 24 p. 8366 - 8378
反应条件
methanol in tetrahydrofuran; toluene T=20°C; Grignard Reaction; Flow reactor; TemperatureSolvent;
参考文献
Kupracz, Lukas; Kirschning, Andreas
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 17 p. 3375 - 3380
反应条件
1: n-butyllithium; carbon dioxide / tetrahydrofuran; hexane / -50 - 20 °C / 3878.71 Torr / |Flow reactor 2: methanol / tetrahydrofuran; toluene / 20 °C / |Flow reactor View Scheme
参考文献
Advanced Synthesis and Catalysis, , vol. 355, # 17 p. 3375 - 3380
反应条件
in ethanol T=200°C; P=82508.3 Torr; 0.01 h; Flow reactor; SolventTemperature;
参考文献
Kupracz, Lukas; Kirschning, Andreas
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 17 p. 3375 - 3380
反应条件
1: benzene / Heating 2: aq. HBr / acetic acid / Heating View Scheme
参考文献
Collection of Czechoslovak Chemical Communications, , vol. 32, # 8 p. 2826 - 2839
反应条件
hydrogenchloride in ethanol Heating;
参考文献
Hudgens, Debjani P.; Taylor, Catherine; Batts, Timothy W.; Patel, Manoj K.; Brown, Milton L.
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 24 p. 8366 - 8378
