1-Cbz-4-(2-羟基乙基)-哌啶合成路线 (共 5 条)
反应条件
triethylamine in acetonitrile T=20°C;
参考文献
F. HOFFMANN-LA ROCHE AG
Patent: WO2005/5397 A1, 2005 ;
Location in patent: Page/Page column 61 ;
WO 2005/005397 A1
反应条件
Yield given. Multistep reaction;
参考文献
Brehm, Renate; Ohnhaeuser, Dieter; Gerlach, Hans
Helvetica Chimica Acta, 1987 , vol. 70, p. 1981 - 1987
反应条件
triethylamine in dichloromethane; dimethyl sulfoxide; ethyl acetate
参考文献
US5221671 A1, ;
US 5221671 A
反应条件
sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine T=0 - 5°C; 1.5 h; Inert atmosphere;
参考文献
US2010/143301 A1, ;
Page/Page column 106-107 ;
反应条件
carbon tetrabromide; triphenylphosphine in dichloromethane
T=0 - 20°C;
参考文献
F. HOFFMANN-LA ROCHE AG
Patent: WO2005/5397 A1, 2005 ;
Location in patent: Page/Page column 61-62 ;
WO 2005/005397 A1