1: With isopropylmagnesium chloride in tetrahydrofuran T=-78°C; 1.25 h; Inert atmosphereCooling with acetone-dry ice; 2: With iodine in tetrahydrofuran T=-78 - 20°C; Inert atmosphere; regioselective reaction;

dihydrogen peroxide in acetic anhydride Ambient temperature;

1: 1) KOH / 1) DMSO, 50 deg C, 20 min, 2) DMSO, 50 deg C, 30 min 2: 67.9 percent / 30percent H2O2 / acetic anhydride / Ambient temperature View Scheme

1: 64.4 percent / conc. H2SO4, 100percent HNO3 / Ambient temperature 2: 34 percent / PCl3 / CHCl3 / 1 h / Heating 3: 80.4 percent / NaOMe / Heating View Scheme

1: 64.4 percent / conc. H2SO4, 100percent HNO3 / Ambient temperature 2: 34 percent / PCl3 / CHCl3 / 1 h / Heating View Scheme