5-(4-氟苯基)噻吩-2-羧酸合成路线 （共 4 条）
反应条件
sodium hydroxide; water in tetrahydrofuran; methanol T=60°C; 3 h;
参考文献
Fujisawa Pharmaceutical Co., Ltd.
Patent: US6770667 B1, 2004 ;
Location in patent: Page column 13 ;
反应条件
ethylaluminum dichloride in hexane; toluene T=100°C; P=22502.3 Torr; 3 h; AutoclaveInert atmosphere; regioselective reaction;
参考文献
Nemoto, Koji; Onozawa, Satoru; Konno, Megumi; Morohashi, Naoya; Hattori, Tetsutaro
Bulletin of the Chemical Society of Japan, 2012 , vol. 85, # 3 p. 369 - 371
反应条件
1: potassium fluoride / palladium diacetate / ethanol / 2 h / 110 °C / Microwave irradiation 2: sodium hydroxide; ethanol / 4 h / 70 °C View Scheme
参考文献
WO2012/59443 A2, ;
WO 2012/059443 A2
反应条件
1: potassium fluoride / palladium diacetate / ethanol / 2 h / 110 °C / Microwave irradiation 2: sodium hydroxide; ethanol / 4 h / 70 °C View Scheme
参考文献
WO2012/59443 A2, ;
WO 2012/059443 A2
