hydrogenchloride; water in acetonitrile T=45°C; 24 - 48 h;

1.1: potassium carbonate / toluene; water / 1 h / 65 °C / |Inert atmosphere 1.2: 2 h / 80 °C / |Inert atmosphere 2.1: urea hydrogen peroxide addition compound; phthalic anhydride / water; ethyl acetate / 45 °C 3.1: trifluoromethanesulfonic anhydride; pyridine / acetonitrile / 1.33 h / 70 - 75 °C 3.2: 2 h / 20 °C 4.1: triethylamine; 4-(N,N-dimethlyamino)pyridine / toluene / 2 h 5.1: hydrogenchloride; water / acetonitrile / 40 - 45 °C View Scheme

1.1: urea hydrogen peroxide addition compound; phthalic anhydride / water; ethyl acetate / 45 °C 2.1: trifluoromethanesulfonic anhydride; pyridine / acetonitrile / 1.33 h / 70 - 75 °C 2.2: 2 h / 20 °C 3.1: triethylamine; 4-(N,N-dimethlyamino)pyridine / toluene / 2 h 4.1: hydrogenchloride; water / acetonitrile / 40 - 45 °C View Scheme

1.1: trifluoromethanesulfonic anhydride; pyridine / acetonitrile / 1.33 h / 70 - 75 °C 1.2: 2 h / 20 °C 2.1: triethylamine; 4-(N,N-dimethlyamino)pyridine / toluene / 2 h 3.1: hydrogenchloride; water / acetonitrile / 40 - 45 °C View Scheme

1: triethylamine; 4-(N,N-dimethlyamino)pyridine / toluene / 2 h 2: hydrogenchloride; water / acetonitrile / 40 - 45 °C View Scheme

1.1: bis(dibenzylideneacetone)-palladium(0); sodium salt of phosphorous acid; tri-tert-butyl phosphine / toluene; hexane / 0.85 h / 23 °C / |Inert atmosphere 1.2: 0.75 h / 70 °C / |Inert atmosphere 2.1: hydrogenchloride / dimethyl sulfoxide; water / 1.33 h / 40 - 75 °C 3.1: potassium hydroxide; tetra-n-octylammonium bromide / water / 1 h / 70 °C 4.1: sodium hydroxide; water / ethanol / 80 °C 5.1: thionyl chloride / toluene / 0.5 h / 60 °C 6.1: triethylamine; 4-(N,N-dimethlyamino)pyridine / toluene / 2 h 7.1: hydrogenchloride; water / acetonitrile / 40 - 45 °C View Scheme

1: hydrogenchloride / dimethyl sulfoxide; water / 1.33 h / 40 - 75 °C 2: potassium hydroxide; tetra-n-octylammonium bromide / water / 1 h / 70 °C 3: sodium hydroxide; water / ethanol / 80 °C 4: thionyl chloride / toluene / 0.5 h / 60 °C 5: triethylamine; 4-(N,N-dimethlyamino)pyridine / toluene / 2 h 6: hydrogenchloride; water / acetonitrile / 40 - 45 °C View Scheme

1: sodium hydroxide; water / ethanol / 80 °C 2: thionyl chloride / toluene / 0.5 h / 60 °C 3: triethylamine; 4-(N,N-dimethlyamino)pyridine / toluene / 2 h 4: hydrogenchloride; water / acetonitrile / 40 - 45 °C View Scheme

1.1: Vitride® / toluene / 2 h / 15 - 40 °C 1.2: 0.5 h / 40 - 50 °C 2.1: 4-(N,N-dimethlyamino)pyridine; thionyl chloride / tert-butyl methyl ether / 1 h / 15 - 30 °C 3.1: dimethyl sulfoxide / 1 h / 30 - 40 °C 3.2: 0.5 h 4.1: potassium hydroxide; tetra-n-octylammonium bromide / water / 1 h / 70 °C 5.1: sodium hydroxide; water / ethanol / 80 °C 6.1: thionyl chloride / toluene / 0.5 h / 60 °C 7.1: triethylamine; 4-(N,N-dimethlyamino)pyridine / toluene / 2 h 8.1: hydrogenchloride; water / acetonitrile / 40 - 45 °C View Scheme

1: thionyl chloride / toluene / 0.5 h / 60 °C 2: triethylamine; 4-(N,N-dimethlyamino)pyridine / toluene / 2 h 3: hydrogenchloride; water / acetonitrile / 40 - 45 °C View Scheme