N-Boc-4-氨基-3-吡啶甲醛合成路线 （共 10 条）
反应条件
tert.-butyl lithium in tetrahydrofuran; pentane 1.) -78 deg C, 15 min, -20 deg C, 1.5 h, 2.) -15 deg C to room temperature;
参考文献
Venuti, Michael C.; Stephenson, Robert A.; Alvarez, Robert; Bruno, John J.; Strosberg, Arthur M.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 11 p. 2136 - 2145
反应条件
1: pyridin-4-yl-carbamic acid tert-butyl ester With tert.-butyl lithium in tetrahydrofuran; pentane T=-78 - -20°C; 1 h; 2: N,N-dimethyl-formamide in tetrahydrofuran; pentane T=-15 - 20°C; 16 h; 3: hydrogenchloride; water in tetrahydrofuran; pentane
参考文献
BAYER HEALTHCARE AG
Patent: WO2005/113552 A1, 2005 ;
Location in patent: Page/Page column 21 ;
反应条件
1: 75 percent / tetrahydrofuran / 1 h / Ambient temperature 2: 67 percent / 1.) tert-butyllithium / tetrahydrofuran; pentane / 1.) -78 deg C, 15 min, -20 deg C, 1.5 h, 2.) -15 deg C to room temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 31, # 11 p. 2136 - 2145
反应条件
1: 75 percent / tetrahydrofuran / 1 h / Ambient temperature 2: 67 percent / 1.) tert-butyllithium / tetrahydrofuran; pentane / 1.) -78 deg C, 15 min, -20 deg C, 1.5 h, 2.) -15 deg C to room temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 31, # 11 p. 2136 - 2145
参考文献
WO2006/59164 A2, ;
Page/Page column 37 ;
反应条件
trifluoroacetic acid in dichloromethane
参考文献
Chan, Laval; Jin, Haolun; Stefanac, Tomislav; Lavallee, Jean-Francois; Falardeau, Guy; Wang, Wei; Bedard, Jean; May, Suzanne; Yuen, Leonard
Journal of Medicinal Chemistry, 1999 , vol. 42, # 16 p. 3023 - 3025
反应条件
N-iodo-succinimide; potassium carbonate T=20°C; 1 h;
参考文献
CYTOKINETICS, INC.; SMITHKLINE BEECHAM CORPORATION
Patent: WO2003/103575 A2, 2003 ;
Location in patent: Page 74 ;
反应条件
1: 90 percent / TFA / CH2Cl2 2: 90 percent / aq. NaOH 3: 59 percent / Br2 / acetic acid View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 42, # 16 p. 3023 - 3025
反应条件
1: 90 percent / TFA / CH2Cl2 2: 90 percent / aq. NaOH View Scheme
参考文献
Chan, Laval; Jin, Haolun; Stefanac, Tomislav; Lavallee, Jean-Francois; Falardeau, Guy; Wang, Wei; Bedard, Jean; May, Suzanne; Yuen, Leonard
Journal of Medicinal Chemistry, 1999 , vol. 42, # 16 p. 3023 - 3025
反应条件
sodium tetrahydroborate in methanol
T=20°C; 1 h;
参考文献
Mochizuki, Akiyoshi; Nagata, Tsutomu; Kanno, Hideyuki; Suzuki, Makoto; Ohta, Toshiharu
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 5 p. 1623 - 1642
