2-Boc-氨基-3-吡啶甲醛合成路线 （共 8 条）
反应条件
1: pyridin-2-yl-carbamic acid tert-butyl ester With tert.-butyl lithium in diethyl ether T=-78 - 0°C; 1 h; Inert atmosphere; 2: N,N-dimethyl-formamide in diethyl ether T=0°C; 0.166667 h;
参考文献
WO2013/64231 A1, ;
Page/Page column 45 ;
WO 2013/064231 A1
反应条件
tert.-butyl lithium in tetrahydrofuran; pentane 1.) -78 deg C, 15 min, -20 deg C, 1.5 h, 2.) -15 deg C to room temperature;
参考文献
Journal of Medicinal Chemistry, , vol. 31, # 11 p. 2136 - 2145
反应条件
in diethyl ether; ethyl acetate
参考文献
US6479512 B1, ;
US 6479512 B1
反应条件
1: 87 percent / 2-methyl-propan-2-ol / Ambient temperature 2: 58 percent / 1.) tert-butyllithium / tetrahydrofuran; pentane / 1.) -78 deg C, 15 min, -20 deg C, 1.5 h, 2.) -15 deg C to room temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 31, # 11 p. 2136 - 2145
反应条件
1: 87 percent / 2-methyl-propan-2-ol / Ambient temperature 2: 58 percent / 1.) tert-butyllithium / tetrahydrofuran; pentane / 1.) -78 deg C, 15 min, -20 deg C, 1.5 h, 2.) -15 deg C to room temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 31, # 11 p. 2136 - 2145
反应条件
1.1: tert-butyl alcohol / 30 - 40 °C / Inert atmosphere 2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere 2.2: -78 - -20 °C / Inert atmosphere 2.3: -78 - 20 °C / Inert atmosphere View Scheme
参考文献
Heterocyclic Communications, , vol. 17, # 1-2 p. 21 - 23
反应条件
1: trifluoroacetic acid / dichloromethane / 20 °C / Inert atmosphere 2: N-chloro-succinimide / acetonitrile / 2 h / Reflux; Inert atmosphere View Scheme
参考文献
Hou, Chuan-Jin; Guo, Wei-Lei; Liu, Xiao-Ning; Yang, Da-Wei
Heterocyclic Communications, 2011 , vol. 17, # 1-2 p. 21 - 23
反应条件
1: 84 percent / NaH / dimethylformamide; various solvent(s) / 0 - 20 °C
2: PPh3 / CH2Cl2 / 0 - 20 °C
3: 0.160 g / aq. HCl / 0.5 h / 75 °C
4: 84 percent / K3PO4*H2O; S-Phos / Pd(OAc)2 / toluene / 2 h / 100 °C
View Scheme
参考文献
Fang, Yuan-Qing; Yuen, Josephine; Lautens, Mark
Journal of Organic Chemistry, 2007 , vol. 72, # 14 p. 5152 - 5160
