(2-溴-3-吡啶基)氨基甲酸叔丁酯合成路线 （共 7 条）
反应条件
1: 3-amino-2-bromo-pyridine With sodium hexamethyldisilazane in tetrahydrofuran T=0°C; 2: di-tert-butyl dicarbonate in tetrahydrofuran T=20°C; 1.5 h;
参考文献
Kowol, Christian R.; Trondl, Robert; Heffeter, Petra; Arion, Vladimir B.; Jakupec, Michael A.; Roller, Alexander; Galanski, Markus; Berger, Walter; Keppler, Bernhard K.
Journal of Medicinal Chemistry, 2009 , vol. 52, # 16 p. 5032 - 5043
反应条件
diphenyl phosphoryl azide T=80°C; 3 h;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2004/110996 A1, 2004 ;
Location in patent: Page/Page column 28 ;
WO 2004/110996 A1
反应条件
N-bromosuccinmide; triethylamine; 2-(N,N-dimethylamino)-pyridine in N-methyl-acetamide; dichloromethane; ethyl acetate
反应条件
1: 3-amino-2-bromo-pyridine With sodium hexamethyldisilazane in tetrahydrofuran T=0 - 20°C; 2: trimethylacetic anhydride in tetrahydrofuran T=20°C;
参考文献
WO2009/140642 A2, ;
Page/Page column 85 ;
WO 2009/140642 A2
反应条件
sodium hexamethyldisilazane in tetrahydrofuran
反应条件
n-butyllithium in tetrahydrofuran; hexane 1.) -78 deg C, 1 h, 2.) -78 deg C to 0 deg C, 0 deg C, 1 h;
参考文献
Venuti, Michael C.; Stephenson, Robert A.; Alvarez, Robert; Bruno, John J.; Strosberg, Arthur M.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 11 p. 2136 - 2145
反应条件
1: sodium hydride / N,N-dimethyl-formamide / 1.5 h / 0 - 5 °C
2: trifluoroacetic acid / dichloromethane / 2 h / 0 - 25 °C
View Scheme
参考文献
Lach, Franck; Koza, Patrice
ACS Combinatorial Science, 2012 , vol. 14, # 9 p. 491 - 495
