(2-甲酰基吡啶-3-基)氨基甲酸叔丁酯合成路线 （共 7 条）
反应条件
n-butyllithium in tetrahydrofuran; hexane 1.) -78 deg C, 1 h, 2.) -78 deg C to 0 deg C, 0 deg C, 1 h;
参考文献
Venuti, Michael C.; Stephenson, Robert A.; Alvarez, Robert; Bruno, John J.; Strosberg, Arthur M.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 11 p. 2136 - 2145
反应条件
1.1: 75 percent / sodium bicarbonate; triphenylphosphine / Pd(OAc)2 / dimethylformamide / 24 h / 130 °C 2.1: 2-methyl-propan-2-ol / 20 - 40 °C 3.1: O3 / methanol; CH2Cl2 / 0.75 h / -78 °C 3.2: 5.23 g / Me2S / methanol; CH2Cl2 / 20 °C View Scheme
参考文献
Tetrahedron, , vol. 54, # 23 p. 6311 - 6318
反应条件
1: 91 percent / triethylamine, diphenyl phosphorazidate / 2 h / Heating 2: 90 percent / 1.) n-butyllithium / tetrahydrofuran; hexane / 1.) -78 deg C, 1 h, 2.) -78 deg C to 0 deg C, 0 deg C, 1 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 31, # 11 p. 2136 - 2145
反应条件
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 0 °C 1.2: 1.5 h / 20 °C 2.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C / |Inert atmosphere 2.2: 1 h / 0 °C View Scheme
参考文献
WO2013/64231 A1, ;
WO 2013/064231 A1
反应条件
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 0 °C 1.2: 1.5 h / 20 °C 2.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C / |Inert atmosphere 2.2: 1 h / 0 °C View Scheme
参考文献
WO2013/64231 A1, ;
WO 2013/064231 A1
反应条件
sodium tetrahydroborate in methanol
参考文献
Mochizuki, Akiyoshi; Nagata, Tsutomu; Kanno, Hideyuki; Suzuki, Makoto; Ohta, Toshiharu
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 5 p. 1623 - 1642
反应条件
hydrogenchloride in ethanol; water
Condensation; deprotection; 3 h; Heating;
参考文献
Niu, Chuansheng; Li, Jun; Doyle, Terrence W.; Chen, Shu-Hui
Tetrahedron, 1998 , vol. 54, # 23 p. 6311 - 6318
