aluminum oxide T=290 - 310°C;

2,2,6,6-tetramethyl-1-piperidinyloxy, free radical; Candida antarctica B lipase; [RuCl2(p-cymene)]2; (E)-2-((1-hydroxy-2-methylpropan-2-ylimino)methyl)phenol in toluene T=70°C; 72 h; Inert atmosphereEnzymatic reaction; optical yield given as percent eeenantioselective reaction;

2,2,6,6-tetramethyl-piperidine-N-oxyl; iron(III) chloride in water; ethyl acetate T=20°C; 5 h;

1: oxalic acid, AcOH / H2O / 5 h / Heating 2: K2CO3 / acetone / 8 h / Heating View Scheme

1: oxalic acid, AcOH / H2O / 5 h / Heating 2: 9.2 g / K2CO3 / acetone / 8 h / Heating View Scheme

Multi-step reaction with 3 steps 1: triethylamine; 4-(N,N-dimethlyamino)pyridine / diethyl ether2: sodium carbonate / toluene / 72 h / 40 °C / |Schlenk technique; |Resolution of racemate; |Enzymatic reaction3: di-isopropyl azodicarboxylate; triphenylphosphine / 24 h / 0 - 20 °C