2-氨基-6-溴噻唑并[5,4-b]吡啶合成路线 （共 6 条）
反应条件
1: With sulfuric acid in water T=140°C; 1 h; 2: With sodium hydroxide in water pH=8;
参考文献
WO2009/74812 A1, ;
Page/Page column 91; 92 ;
WO 2009/074812 A1
反应条件
1: With copper(l) iodide; caesium carbonate; DL-proline in dimethyl sulfoxide 2 h; 2: With ammonia in water pH=8;
参考文献
WO2012/7510 A1, ;
Page/Page column 58 ;
反应条件
1: 5-bromo-2-chloro-pyridin-3-ylamine With hydrogenchloride in water Sonicated; 2: potassium thioacyanate in water T=100°C; 6.5 h; Reflux; 3: With sodium carbonate in water
参考文献
WO2009/147431 A1, ;
Page/Page column 51; 52 ;
WO 2009/147431 A1
反应条件
in sulfolane T=135°C; 0.75 h; Microwave irradiation;
参考文献
Journal of Heterocyclic Chemistry, , vol. 46, # 6 p. 1125 - 1131
反应条件
1.1: benzoyl chloride / acetone / 0.25 h / Reflux 1.2: 1.5 h / 40 °C / Reflux 1.3: 2 h / 60 °C 2.1: caesium carbonate; copper(l) iodide; DL-proline / dimethyl sulfoxide / 2 h 2.2: pH 8 View Scheme
反应条件
tert.-butylnitrite; copper dichloride in acetonitrile T=0 - 20°C;
参考文献
BAYER PHARMA AKTIENGESELLSCHAFT; ROeHN, Ulrike; SCHMITT-WILLICH, Heribert; HEINRICH, Tobias; BERGER, Markus; FITZNER, Ansgar; KRAUSE, Sabine; BROCKSCHNIEDER, Damian; DYRKS, Thomas; THIELE, Andrea; MOeNNING, Ursula; BOeMER, Ulf
Patent: WO2012/7510 A1, 2012 ;
Location in patent: Page/Page column 58-59 ;
