1-(5-溴-3-氟吡啶-2-基)乙酮合成路线 （共 4 条）
反应条件
1: in diethyl ether; toluene T=-10 - 0°C; 1 h; Inert atmosphere; 2: With hydrogenchloride in diethyl ether; water; toluene T=20°C; 18 h;
参考文献
WO2012/13643 A1, ;
Page/Page column 76 ;
反应条件
in tetrahydrofuran; toluene T=20°C; 0.333333 h;
参考文献
Sato Pharmaceutical Co., Ltd.; NAGAI Keita; NAGASAWA Koh; TAKAHASHI Hirobumi; BABA Motoaki; FUJIOKA Shinichi; KONDOH Eri; TANAKA Kenichi; ITOH Yoshiki
Patent: EP2669270 A1, 2013 ;
Location in patent: Paragraph 0895-0896 ;
反应条件
1.1: tetrabutyl ammonium fluoride / N,N-dimethyl-formamide / 0.5 h / -15 °C / Molecular sieve 1.2: 1 h 2.1: toluene; diethyl ether / 1 h / -10 - 0 °C / Inert atmosphere 2.2: 18 h / 20 °C View Scheme
反应条件
1: N,N-dimethyl-formamide / 0.5 h / 120 °C / Inert atmosphere; microwave irradiation 2: trifluoroacetic acid / dichloromethane / 0.5 h View Scheme
参考文献
TIBOTEC PHARMACEUTICALS; VANDYCK, Koen; VERSCHUEREN, Wim Gaston; RABOISSON, Pierre Jean-Marie Bernard
Patent: WO2012/13643 A1, 2012 ;
