2,4-二氯-6-硝基吡咯并[2,1-f][1,2,4]三嗪合成路线 （共 2 条）
反应条件
triethylamine; trichlorophosphate Inert atmosphereReflux;
参考文献
Abraham, Sunny; Hadd, Michael J.; Tran, Lan; Vickers, Troy; Sindac, Janice; Milanov, Zdravko V.; Holladay, Mark W.; Bhagwat, Shripad S.; Hua, Helen; Ford Pulido, Julia M.; Cramer, Merryl D.; Gitnick, Dana; James, Joyce; Dao, Alan; Belli, Barbara; Armstrong, Robert C.; Treiber, Daniel K.; Liu, Gang
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 18 p. 5296 - 5300
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C 1.2: 20 °C 2.1: ammonia / methanol / -10 - 80 °C / Sealed tube 3.1: pyridine / 1,4-dioxane / 1 h / Reflux 4.1: triethylamine; trichlorophosphate / Inert atmosphere; Reflux View Scheme
参考文献
AMBIT BIOSCIENCES CORPORATION; ABRAHAM, Sunny; BHAGWAT, Shripad, S.; HADD, Michael, J.; HOLLADAY, Mark, W.; LIU, Gang; MILANOV, Zdravko, V.; PATEL, Hitesh, K.; SETTI, Eduardo; SINDAC, Janice, A.
Patent: WO2011/88045 A1, 2011 ;
WO 2011/088045 A1
