N-苄氧羰基-L-苯丙氨酸合成路线 （共 122 条）
反应条件
1: tetrahydrofuran / 0.25 h / 0 °C 2: sodium azide / tetrahydrofuran; dimethyl sulfoxide / 0.33 h / 0 °C 3: tetrahydrofuran; dimethyl sulfoxide / 0.17 h / Sonication View Scheme
参考文献
Vasantha; Vishwanatha; Sureshbabu, Vommina V.
Protein and Peptide Letters, 2011 , vol. 18, # 11 p. 1093 - 1098
反应条件
dicyclohexyl-carbodiimide in tetrahydrofuran T=0°C; 18 h;
参考文献
Dechert, Anne-Marie R.; MacNamara, James P.; Breevoort, Sarah R.; Hildebrandt, Emily R.; Hembree, Ned W.; Rea, Adam C.; McLain, Duncan E.; Porter, Stephen B.; Schmidt, Walter K.; Dore, Timothy M.
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 17 p. 6230 - 6237
反应条件
4-methyl-morpholine in tetrahydrofuran; acetonitrile Ambient temperature;
参考文献
Jaoudai, Mahmoud; Martinez, Jean; Castro, Bertrand
Journal of Organic Chemistry, 1987 , vol. 52, # 12 p. 2364 - 2367
反应条件
1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide in tetrahydrofuran T=0°C; 5 h;
参考文献
Samai, Suman; Dey, Joykrishna; Biradha, Kumar
Soft Matter, 2011 , vol. 7, # 5 p. 2121 - 2126
反应条件
pyridine in acetonitrile 5 h;
参考文献
Takeda, Kazuyoshi; Sawada, Izumi; Suzuki, Akira; Ogura, Haruo
Tetrahedron Letters, 1983 , vol. 24, # 41 p. 4451 - 4454
反应条件
4-(N,N-dimethlyamino)pyridine in acetonitrile 4 h; Ambient temperature;
参考文献
Takeda; Ayabe; Suzuki; Konda; Harigaya
Synthesis, 1991 , # 9 p. 689 - 691
反应条件
pyridine in acetonitrile
参考文献
Griffin, Martin; Mongeot, Alexandre; Collighan, Russell; Saint, Robert E.; Jones, Richard A.; Coutts, Ian G.C.; Rathbone, Daniel L.
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 20 p. 5559 - 5562
反应条件
1: N-benzyloxycarbonyl-L-phenylalanine With chloroformic acid ethyl ester; triethylamine in tetrahydrofuran; diethyl ether T=-25°C; 0.5 h; 2: diazomethane in tetrahydrofuran; diethyl ether T=-10 - 20°C; 3 h;
参考文献
Bures, Filip; Kulhanek, Jiri
Tetrahedron Asymmetry, 2005 , vol. 16, # 7 p. 1347 - 1354
反应条件
4-methyl-morpholine in tetrahydrofuran; di-isopropyl ether; ethyl acetate
参考文献
E. R. Squibb and Sons, Inc.
Patent: US4500518 A1, 1985 ;
US 4500518 A
反应条件
1: Et3N / diethyl ether; tetrahydrofuran / 0.5 h / -25 °C 2: diethyl ether / 3 h / -10 °C View Scheme
参考文献
Yoakim, Christiane; Ogilvie, William W.; Cameron, Dale R.; Chabot, Catherine; Guse, Ingrid; Hache, Bruno; Naud, Julie; O'Meara, Jeff A.; Plante, Raymond; Deziel, Robert
Journal of Medicinal Chemistry, 1998 , vol. 41, # 15 p. 2882 - 2891
