N-苄氧羰基-L-苯丙氨酸合成路线 （共 122 条）
反应条件
triethylamine in ethyl acetate
参考文献
Itoh
Bulletin of the Chemical Society of Japan, 1974 , vol. 47, # 2 p. 471 - 475
反应条件
sodium hydrogencarbonate; N,N-dimethyl-formamide
参考文献
Bocchi,V. et al.
Synthesis, 1979 , p. 961 - 962
反应条件
1: N-benzyloxycarbonyl-L-phenylalanine With 4-methyl-morpholine; isobutyl chloroformate in tetrahydrofuran
T=-25°C;
2: N-(tert-butoxycarbonyl)lalanine amide With sodium hydroxide in tetrahydrofuran; water
T=20°C; 2 h;
参考文献
Loeser, Reik; Frizler, Maxim; Schilling, Klaus; Guetschow, Michael
Angewandte Chemie - International Edition, 2008 , vol. 47, # 23 p. 4331 - 4334
反应条件
2: palladium; acetic acid / Hydrogenation
View Scheme
参考文献
Theodoropoulos,D.; Gazopoulos,J.
Journal of Organic Chemistry, 1962 , vol. 27, p. 2091 - 2093
反应条件
1: pTSA
2: 96 percent / toluene / 3 h / Heating
3: 98 percent / H2; trifluoroacetic acid / Pd/C / methanol / 2 h / 20 °C
4: 92 percent / Et3N / methanol / 8 h / 20 °C
5: NaBH4 / methanol / 1 h / 0 - 20 °C
View Scheme
参考文献
Reddy, G. Vidyasagar; Rao, G. Venkat; Iyengar, D. S.
Chemistry Letters, 1999 , # 7 p. 703 - 704
反应条件
triethylamine; isobutyl chloroformate
1.) diethyl ether, tetrahydrofuran, -20 deg C, 15 min 2.) diethyl ether, tetrahydrofuran, 1 h at -10 deg C then 12 h at 5 deg C; Yield given. Multistep reaction;
参考文献
Plucinska, Krystyna; Liberek, Bogdan
Tetrahedron, 1987 , vol. 43, # 15 p. 3509 - 3518
反应条件
1: 1.) N-ethylmorpholine, isobutylchloroformate; 2.) NH3 / 1.) THF, -15 deg C, 5 min; 2.) THF, 30 min
2: H2 / Pd/C / dimethylformamide
3: pyridine
View Scheme
参考文献
Blackburn, G. Michael; Kent, Hilary E.; Lilley, Terence H.
Journal of the Chemical Society, Faraday Transactions 1: Physical Chemistry in Condensed Phases, 1985 , vol. 81, p. 2207 - 2214
反应条件
1: N-methylmorpholine / CH2Cl2 / 0.25 h / -15 °C
2: CH2Cl2 / 0 - 20 °C
3: aq. LiOH / tetrahydrofuran / 0 - 22 °C
View Scheme
参考文献
Kanosue, Yoshifumi; Kojima, Satoshi; Hiraga, Yoshikazu; Ohkata, Katsuo
Bulletin of the Chemical Society of Japan, 2004 , vol. 77, # 6 p. 1187 - 1193
反应条件
chloro-trimethyl-silane; pivaloyl chloride; triethylamine
1) CH2Cl2-DMFA (5:1), 20 min, room temp.; 2) CH2Cl2, -5 deg C, 1 h, 0 deg C, 12 h.; Yield given. Multistep reaction;
参考文献
Krysin, E. P.; Karel'skii, V. N.; Rabinovich, A. K.; Borovkova, S. Yu.
Chemistry of Natural Compounds, 1986 , vol. 22, # 6 p. 706 - 709
Khimiya Prirodnykh Soedinenii, 1986 , vol. 22, # 6 p. 759 - 763
反应条件
4-(N,N-dimethlyamino)pyridine; TEA
T=35°C; 0.5 h;
参考文献
Jouin, P.; Castro, B.; Zeggaf, C.; Pantaloni, A.; Senet, J.P.; et. al
Tetrahedron Letters, 1987 , vol. 28, # 15 p. 1661 - 1664
