N-苄氧羰基-L-苯丙氨酸合成路线 （共 122 条）
反应条件
1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere 2: palladium 10 on activated carbon; hydrogen / ethanol; triethylamine / 3102.97 Torr 3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere View Scheme
参考文献
Peuchmaur, Marine; Lacour, Marie-Agnes; Sevalle, Jean; Lisowski, Vincent; Touati-Jallabe, Youness; Rodier, Fabien; Martinez, Jean; Checler, Frederic; Hernandez, Jean-Francois
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 4 p. 1018 - 1029
反应条件
1: ethyl chloroformate; aq. ammonia; triethylamine / tetrahydrofuran / 0.5 h / 0 °C 2: 7.7 g / phosphorus oxychloride; pyridine / 0 - 20 °C View Scheme
参考文献
Delacroix, Sebastien; Bonnet, Jean-Pierre; Courty, Matthieu; Postel, Denis; Van Nhien, Albert Nguyen
Carbohydrate Research, 2013 , vol. 381, p. 12 - 18
反应条件
1: 1.) N-ethylmorpholine, isobutylchloroformate; 2.) NH3 / 1.) THF, -15 deg C, 5 min; 2.) THF, 30 min 2: H2 / Pd/C / dimethylformamide View Scheme
参考文献
Davey; Laird; Morley
Journal of the Chemical Society. Perkin transactions 1, 1966 , vol. 5, p. 555 - 566
反应条件
di-tert-butyl dicarbonate; BBDI in dichloromethane T=20°C; 24 h;
参考文献
Saito, Yukako; Watanabe, Tomokazu; Takahata, Hiroki
Tetrahedron Letters, 2006 , vol. 47, # 18 p. 3099 - 3102
反应条件
4-(N,N-dimethlyamino)pyridine in neat (no solvent) 1 h; Milling;
参考文献
Konnert, Laure; Lamaty, Frederic; Martinez, Jean; Colacino, Evelina
Journal of Organic Chemistry, 2014 , vol. 79, # 9 p. 4008 - 4017
反应条件
Aliquatreg; 336; sodium hydrogencarbonate in dichloromethane
参考文献
Bocchi,V. et al.
Synthesis, 1979 , p. 957 - 961
反应条件
in neat (no solvent) Milling;
参考文献
Konnert, Laure; Lamaty, Frederic; Martinez, Jean; Colacino, Evelina
Journal of Organic Chemistry, 2014 , vol. 79, # 9 p. 4008 - 4017
反应条件
1: DCC 2: H2, HCl / Pd-C / ethanol View Scheme
参考文献
Goldstein,T.P. et al.
Journal of Medicinal and Pharmaceutical Chemistry, 1962 , vol. 5, p. 852 - 857
反应条件
1: With 1-propanephosphonic acid cyclic anhydride; N-ethyl-N,N-diisopropylamine in ethyl acetate T=0°C; 0.166667 h; 2: With sodium tetrahydroborate in water; ethyl acetate T=0°C; 0.416667 h;
参考文献
Nagendra; Madhu; Vishwanatha; Sureshbabu, Vommina V.
Tetrahedron Letters, 2012 , vol. 53, # 38 p. 5059 - 5063
反应条件
perchloric acid; triphenylphosphine in dichloromethane T=-30°C; electrolysis, 2.8 F of electricity, graphite plates as anode and cathode;
参考文献
Maeda, Hatsuo; Maki, Toshihide; Ohmori, Hidenobu
Tetrahedron Letters, 1992 , vol. 33, # 10 p. 1347 - 1350
