N-苄氧羰基-L-苯丙氨酸合成路线 （共 122 条）
反应条件
(i) DMF, (ii) /BRN= 2222826/, Et3N; Multistep reaction;
参考文献
Itoh,M.
Chemical and Pharmaceutical Bulletin, 1970 , vol. 18, # 4 p. 784 - 788
反应条件
triethylamine in ethyl acetate
参考文献
Fujisawa Pharmaceutical Co., Ltd.
Patent: US3976635 A1, 1976 ;
反应条件
(i) (CF3CO)2O, benzene, (ii) /BRN= 2222826/, Py; Multistep reaction;
参考文献
Horiki, Kusuo; Murakami, Atsuko
Heterocycles, 1989 , vol. 28, # 2 p. 615 - 622
反应条件
(i) DMF, (ii) /BRN= 2222826/, Et3N; Multistep reaction;
参考文献
Itoh,M.
Chemical and Pharmaceutical Bulletin, 1970 , vol. 18, # 4 p. 784 - 788
反应条件
CDI in tetrahydrofuran
参考文献
PHARMACIA and UPJOHN COMPANY
Patent: EP898562 B1, 2003 ;
反应条件
1: N-ethylmorpholine / tetrahydrofuran / 0.5 h / -10 °C 2: 58 percent / tetrahydrofuran / 20 °C 3: 80 percent / H2 / Pd/C / methanol / 3 h / 25 °C / 1551.49 Torr View Scheme
参考文献
Gaeta, Alessandra; Molina-Holgado, Francisco; Kong, Xiao L.; Salvage, Sarah; Fakih, Sarah; Francis, Paul T.; Williams, Robert J.; Hider, Robert C.
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 3 p. 1285 - 1297
反应条件
1: (i) Et3N, THF, (ii) ClCO2Et, (iii) /BRN= 1756967/ 2: H2 / methanol View Scheme
参考文献
Wuensch,E.; Wendlberger,G.
Chemische Berichte, 1964 , vol. 97, p. 2504 - 2514
反应条件
chloro-trimethyl-silane 18 h;
参考文献
Edmonds; Abell
Journal of Organic Chemistry, 2001 , vol. 66, # 11 p. 3747 - 3752
反应条件
potassium hydrogencarbonate; sodium sulfite in water; N,N-dimethyl-formamide
参考文献
Welfide Corporation
Patent: US6528514 B1, 2003 ;
参考文献
Shibuya, Masatoshi; Sato, Takahisa; Tomizawa, Masaki; Iwabuchi, Yoshiharu
Chemical Communications, 2009 , # 13 p. 1739 - 1741
