N-苄氧羰基-L-苯丙氨酸合成路线 （共 122 条）
反应条件
4-(N,N-dimethlyamino)pyridine in tetrahydrofuran 0.5 h;
参考文献
Takeda; Akiyama; Nakamura; Takizawa; Mizuno; Takayanagi; Harigaya
Synthesis, 1994 , # 10 p. 1063 - 1066
反应条件
1: pyridine / acetonitrile / 1 h / Ambient temperature 2: pyridine / acetonitrile / 8 h / Ambient temperature View Scheme
参考文献
Pinho, Vagner D.; Gutmann, Bernhard; Miranda, Leandro S. M.; De Souza, Rodrigo O. M. A.; Kappe, C. Oliver
Journal of Organic Chemistry, 2014 , vol. 79, # 4 p. 1555 - 1562
反应条件
potassium hydrogencarbonate in N,N-dimethyl-formamide 4 h; Ambient temperature;
参考文献
Wyslouch, Aleksandra; Lisowski, Marek; Siemion, Ignacy Z.
Bulletin of the Polish Academy of Sciences, Chemistry, 1994 , vol. 42, # 1 p. 117 - 130
反应条件
in methanol; benzene
参考文献
Hamada; Shioiri
Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 5 p. 1921 - 1924
反应条件
triethylamine; isobutyl chloroformate 1.) diethyl ether, tetrahydrofuran, -20 deg C, 15 min 2.) diethyl ether, tetrahydrofuran, 1 h at -10 deg C then 12 h at 5 deg C; Yield given. Multistep reaction;
参考文献
Plucinska, Krystyna; Liberek, Bogdan
Tetrahedron, 1987 , vol. 43, # 15 p. 3509 - 3518
反应条件
benzotriazol-1-ol; diisopropyl-carbodiimide in ethyl acetate T=20°C; 24 h;
参考文献
Duan, Jianli; Sun, Yao; Chen, Hao; Qiu, Guofu; Zhou, Haibing; Tang, Ting; Deng, Zixin; Hong, Xuechuan
Journal of Organic Chemistry, 2013 , vol. 78, # 14 p. 7013 - 7022
反应条件
1: 88 percent / TEA, DMAP, IPCC / 0.5 h / 35 °C 2: H2 / Pd/C / methanol / 1 h / Ambient temperature View Scheme
参考文献
Anderson,G.W.; Callahan,F.M.
Journal of the American Chemical Society, 1960 , vol. 82, p. 3359 - 3363
反应条件
1: 1.) carbonyldiimidazole 2: NaBH4 / ethanol / 1 h / -15 - -10 °C 3: 89 percent / TsOH*H2O / 5 h / 60 °C 4: 92 percent / 1 M aq. NaOH / ethanol / 18 h / Ambient temperature 5: (COCl)2, DMF / toluene / 1 h 6: CBrCl3, 2-mercaptopyridine N-oxide sodium salt, 4-(dimethylamino)pyridine / 1 h / 80 °C / Irradiation 7: aq. AcOH, conc. HCl / 3 h / Ambient temperature 8: 92 percent / KOH / methanol / 3 h / Ambient temperature 9: 86 percent / propan-2-ol / 6 h / 80 °C 10: 100 percent / H2 / 10percent Pd/C / ethanol / 24 h View Scheme
参考文献
Parkes, Kevin E. B.; Bushnell, David J.; Crackett, Peter H.; Dunsdon, Stephen J.; Freeman, Andrew C.; et al.
Journal of Organic Chemistry, 1994 , vol. 59, # 13 p. 3656 - 3664
反应条件
1: 1.) carbonyldiimidazole 2: NaBH4 / ethanol / 1 h / -15 - -10 °C 3: 89 percent / TsOH*H2O / 5 h / 60 °C 4: 92 percent / 1 M aq. NaOH / ethanol / 18 h / Ambient temperature 5: (COCl)2, DMF / toluene / 1 h 6: CBrCl3, 2-mercaptopyridine N-oxide sodium salt, 4-(dimethylamino)pyridine / 1 h / 80 °C / Irradiation 7: aq. AcOH, conc. HCl / 3 h / Ambient temperature 8: 92 percent / KOH / methanol / 3 h / Ambient temperature 9: 86 percent / propan-2-ol / 6 h / 80 °C 10: 100 percent / H2 / 10percent Pd/C / ethanol / 24 h 11: 48 percent / 1-hydroxybenzotriazole hydrate, dicyclohexylcarbodiimide, N-ethylmorpholine / tetrahydrofuran / 64 h / Ambient temperature 12: H2 / 10percent Pd/C / ethanol / 16 h 13: 1-hydroxybenzotriazole hydrate, dicyclohexylcarbodiimide, N-ethylmorpholine / tetrahydrofuran / 16 h / Ambient temperature View Scheme
参考文献
Parkes, Kevin E. B.; Bushnell, David J.; Crackett, Peter H.; Dunsdon, Stephen J.; Freeman, Andrew C.; et al.
Journal of Organic Chemistry, 1994 , vol. 59, # 13 p. 3656 - 3664
反应条件
1: Et3N / 13 °C / 1.) -10 deg C, 20 min, 2.) RT, 30 min 2: diethyl ether / 0.17 h / Ambient temperature 3: 63 percent / silver benzoate, Et3N / 0.5 h / Ambient temperature 4: 93 percent / H2 / 20percent Pd(OH)2/C / methanol / 7 h / 760 Torr / Ambient temperature View Scheme
参考文献
Yoakim, Christiane; Ogilvie, William W.; Cameron, Dale R.; Chabot, Catherine; Guse, Ingrid; Hache, Bruno; Naud, Julie; O'Meara, Jeff A.; Plante, Raymond; Deziel, Robert
Journal of Medicinal Chemistry, 1998 , vol. 41, # 15 p. 2882 - 2891
