water; sodium chloride in dimethyl sulfoxide T=160°C; 2.5 h;

sodium methylate in methanol T=20°C; 72 h;

1: PhMe2SiCu(Bu)Li With n-butyllithium; copper (I) cyanide in tetrahydrofuran; hexane T=0°C; 0.25 h; 2: trans-glutaconic acid dimethyl ester in tetrahydrofuran; hexane T=-78 - 20°C; Further stages.;

copper(l) iodide; oxygen; tri-phenylphosphine sulphide; palladium dichloride 72 h; Ambient temperature;

1.) CuCN 1.) THF, 0 deg C, 0.5 h, 2.) THF, -78 deg C, 3 h; Yield given. Multistep reaction;