3-氨基-4-氰基-5-(甲基硫代)-噻吩-2-羧酸乙酯合成路线 （共 6 条）
反应条件
triethylamine in methanol 2 h; Reflux;
参考文献
MILLENNIUM PHARMACEUTICALS, INC.; TAKEDA PHARMACEUTICAL COMPANY LIMITED; BANNO, Hiroshi; HIROSE, Masaaki; KURASAWA, Osamu; LANGSTON, Steven, P.; MIZUTANI, Hirotake; SHI, Zhan; VISIERS, Irache; VOS, Tricia, J.; VYSKOCIL, Stepan
Patent: WO2010/90716 A1, 2010 ;
Location in patent: Page/Page column 217-218 ;
参考文献
Aventis Pharma S.A.
Patent: US2008/146542 A1, 2008 ;
Location in patent: Page/Page column 18 ;
反应条件
ethanol T=20°C; 0.333333 h; Green chemistry; regioselective reaction;
参考文献
Luo, Laichun; Meng, Lanlan; Sun, Qi; Ge, Zemei; Li, Runtao
Tetrahedron Letters, 2014 , vol. 55, # 1 p. 259 - 263
反应条件
potassium carbonate in ethanol 6 h; Heating;
参考文献
Sommen, Geoffroy; Comel, Alain; Kirsch, Gilbert
Synthesis, 2003 , # 5 p. 735 - 741
反应条件
in ethanol 96 h; Irradiation;
参考文献
Heterocycles, , vol. 27, # 10 p. 2539 - 2544
反应条件
1: 3-amino-4-cyano-5-methylsulfanylthiophene-2-carboxylic acid ethyl ester With sodium sulfide in N,N-dimethyl-formamide T=50°C; 1 h; 2: chloroacetonitrile With potassium carbonate in N,N-dimethyl-formamide T=50°C; 6 h;
参考文献
Sommen, Geoffroy; Comel, Alain; Kirsch, Gilbert
Synthesis, 2003 , # 5 p. 735 - 741
