lithium hydroxide in tetrahydrofuran; water T=65°C; 16 h;

1: sat. aq. NH4Cl / 0.02 mmol/ml CuCl / diethyl ether; tetrahydrofuran / 1.) -80 deg C, 15 min, 2.) -40 deg C, 16 h 2: 87 percent / 1.) 30 percent aq. H2O2, LiOH*H2O, H2O, 2.) HCl / tetrahydrofuran / 1.) 0 deg C, 2 h, 2.) RT, 16 h View Scheme