3,4-二羟基-5-硝基苯甲醛合成路线 （共 18 条）
反应条件
pyridine; aluminium trichloride in chloroform ether cleavage; 24 h; Heating;
参考文献
Walz; Sundberg
Journal of Organic Chemistry, 2000 , vol. 65, # 23 p. 8001 - 8010
反应条件
acetic acid in conc. hydrobromic acid; water
参考文献
Orion-yhtyma Oy
Patent: US4963590 A1, 1990 ;
US 4963590 A
反应条件
1: diethyl ether; mixture of gaseous nitrogen oxides 2: fuming hydrochloric acid / 140 °C View Scheme
参考文献
Chemische Berichte, , vol. 36, p. 2935
反应条件
1: With piperidine in ethylene glycol dimethyl ether; n-heptane 15 - 25 h; Heating / reflux; 2: in dichloromethane T=25 - 35°C; 24 h; Product distribution / selectivity;
参考文献
SANMAR SPECIALITY CHEMICALS LTD; CHITTOOR, Ghatambu, Sethuram; UDAY, Rajaram, Bapat; MUNUSAMY, Jayamani; MUPPID, Naga, Venkata, Satya, Prasanna, Anjaneya, Radha, Krishna, Murthy
Patent: WO2007/77572 A1, 2007 ;
Location in patent: Page/Page column 5-6 ;
反应条件
1: With piperidine in isopropyl alcohol 12 - 15 h; Heating / reflux; 2: With acetic acid in isopropyl alcohol T=20°C;
参考文献
WOCKHARDT LIMITED; JAWEED MUKARRAM, Siddiqui, Mohammed; KHAN, Rashid, Abdul, Rehman; YADAV, Ram, Prasad; SHAIKH, Zakir, Gafoor
Patent: WO2005/66117 A1, 2005 ;
Location in patent: Page/Page column 11 ;
参考文献
Orion-yhtyma Oy
Patent: US4963590 A1, 1990 ;
US 4963590 A
反应条件
1: piperidine; acetic acid / ethanol / 4 h / 80 °C 2: thionyl chloride / 25 - 80 °C 3: diethylamine / dichloromethane / 2.33 h / -5 - 0 °C View Scheme
参考文献
Srikanth; Ray, Uttam Kumar; Srinivas Rao; Gupta, P. Badarinadh; Lavanya; Islam, Aminul
Synthetic Communications, 2012 , vol. 42, # 9 p. 1359 - 1366
反应条件
ammonium acetate in methanol 4 h; Heating;
参考文献
Baeckstroem, Reijo; Honkanen, Erkki; Pippuri, Aino; Kairisalo, Pekka; Pystynen, Jarmo; et al.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 4 p. 841 - 846
反应条件
1: With piperidine in isopropyl alcohol 12 - 15 h; Heating / reflux; 2: With acetic acid in isopropyl alcohol T=20°C;
参考文献
WOCKHARDT LIMITED; JAWEED MUKARRAM, Siddiqui, Mohammed; KHAN, Rashid, Abdul, Rehman; YADAV, Ram, Prasad; SHAIKH, Zakir, Gafoor
Patent: WO2005/66117 A1, 2005 ;
Location in patent: Page/Page column 11 ;
反应条件
in N,N-dimethyl-formamide T=140°C; Alkylation; 48 h;
参考文献
Walz; Sundberg
Journal of Organic Chemistry, 2000 , vol. 65, # 23 p. 8001 - 8010
