3,4-二羟基-5-硝基苯甲醛合成路线 （共 18 条）
反应条件
1: 85 percent / NaH / dimethylformamide 2: 95 percent / pyridine / CH2Cl2 / 0 - 20 °C View Scheme
参考文献
Fellows, Ingrid M.; Kaelin Jr., David E.; Martin, Stephen F.
Journal of the American Chemical Society, 2000 , vol. 122, # 44 p. 10781 - 10787
反应条件
potassium carbonate in acetone 1.5 h; Reflux;
参考文献
Kiss, Laszlo E.; Ferreira, Humberto S.; Torrao, Leonel; Bonifacio, Maria Joao; Palma, P. Nuno; Soares-Da-Silva, Patricio; Learmonth, David A.
Journal of Medicinal Chemistry, 2010 , vol. 53, # 8 p. 3396 - 3411
反应条件
1: 45 percent / HCl (gas) / tetrahydrofuran / 5 °C 2: 22 percent / Ag2O / various solvent(s) / 24 h / 20 °C View Scheme
参考文献
Baeckstroem, Reijo; Honkanen, Erkki; Pippuri, Aino; Kairisalo, Pekka; Pystynen, Jarmo; et al.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 4 p. 841 - 846
反应条件
formic acid; hydroxylamine hydrochloride 1 h; Heating;
参考文献
Baeckstroem, Reijo; Honkanen, Erkki; Pippuri, Aino; Kairisalo, Pekka; Pystynen, Jarmo; et al.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 4 p. 841 - 846
反应条件
in water; ethyl acetate
参考文献
Hoffmann-La Roche Inc.
Patent: US5236952 A1, 1993 ;
反应条件
hydrogenchloride in tetrahydrofuran T=5°C;
参考文献
Baeckstroem, Reijo; Honkanen, Erkki; Pippuri, Aino; Kairisalo, Pekka; Pystynen, Jarmo; et al.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 4 p. 841 - 846
反应条件
hydrogenchloride in tetrahydrofuran T=5°C;
参考文献
Journal of Medicinal Chemistry, , vol. 32, # 4 p. 841 - 846
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 80 °C
2: AlCl3, aluminium chloride / dichloromethane / 0 - 50 °C
View Scheme
参考文献
N30 PHARMACEUTICALS, LLC; SUN, Xicheng; QIU, Jian
Patent: WO2011/38204 A1, 2011 ;
WO 2011/038204 A1
