4-氟-2-甲基-5-硝基苯甲酸甲酯合成路线 （共 4 条）
反应条件
sulfuric acid; potassium nitrate T=-20 - -10°C; 0.666667 h;
参考文献
BIOENERGENIX
Patent: US2012/277224 A1, 2012 ;
Location in patent: Page/Page column 61 ;
US 20120277224 A1
反应条件
sulfuric acid; potassium nitrate T=-10°C; 4.16667 h;
参考文献
Astellas Pharma Inc.
Patent: US2011/319385 A1, 2011 ;
Location in patent: Page/Page column 21 ;
US 20110319385 A1
反应条件
1: thionyl chloride / 3 h / 80 °C 2: potassium nitrate; sulfuric acid / 0.67 h / -20 - -10 °C View Scheme
参考文献
MERCK PATENT GMBH; YU, Henry; RICHARDSON, Thomas E.; BHARATHI, Pandi; HEASLEY, Brian H.; JENKS, Matthew G.; FOGLESONG, Robert J.
Patent: WO2013/106409 A1, 2013 ;
参考文献
MERCK PATENT GMBH; YU, Henry; RICHARDSON, Thomas E.; BHARATHI, Pandi; HEASLEY, Brian H.; JENKS, Matthew G.; FOGLESONG, Robert J.
Patent: WO2013/106409 A1, 2013 ;
Location in patent: Page/Page column 90 ;
