6-羟基-1H-吲哚-2-甲酸甲酯合成路线 （共 9 条）
反应条件
1: With boron tribromide in dichloromethane T=-78 - 0°C; 0.833333 h; 2: With water in dichloromethane T=0°C;
参考文献
Eisai RandD Management Co., Ltd.
Patent: EP1864980 A1, 2007 ;
Location in patent: Page/Page column 51 ;
反应条件
hydrogen; palladium on activated charcoal in ethyl acetate P=1551.4 Torr; 12 h;
参考文献
Boger, Dale L.; Cerbone, Louis R.; Yohannes, Daniel
Journal of Organic Chemistry, 1988 , vol. 53, # 21 p. 5163 - 5166
反应条件
in methanol; hexane T=20°C;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2008/154271 A1, 2008 ;
Location in patent: Page/Page column 165 ;
反应条件
1: With sulfuric acid 216 h; Heating / reflux; 2: With potassium hydroxide; water pH=9;
参考文献
US2007/259910 A1, ;
Page/Page column 21 ;
反应条件
1: CH3ONa / methanol / 5 h / 0 °C 2: xylene / 7 h / Heating 3: 98 percent / H2 / 10percent Pd/C / ethyl acetate / 12 h / 1551.4 Torr View Scheme
参考文献
Journal of Organic Chemistry, , vol. 53, # 21 p. 5163 - 5166
反应条件
1: xylene / 7 h / Heating 2: 98 percent / H2 / 10percent Pd/C / ethyl acetate / 12 h / 1551.4 Torr View Scheme
参考文献
Journal of Organic Chemistry, , vol. 53, # 21 p. 5163 - 5166
反应条件
1: anhydrous xylene / 6.33 h / Reflux 2: boron tribromide / dichloromethane / 3 h / 0 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 10 p. 3057 - 3061
反应条件
1: sodium methylate / methanol / -8 - 5 °C 2: anhydrous xylene / 6.33 h / Reflux 3: boron tribromide / dichloromethane / 3 h / 0 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 10 p. 3057 - 3061
反应条件
triphenylphosphine; diethylazodicarboxylate in tetrahydrofuran Mitsunobu reaction;
参考文献
Arnaiz, Damian O.; Zhao, Zuchun; Liang, Amy; Trinh, Lan; Whitlow, Marc; Koovakkat, Sunil K.; Shaw, Kenneth J.
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 9 p. 957 - 961
